Treatment of hepatocellular carcinoma with a GPC3-targeted bispecific T cell engager

There are limited strategies for the treatment of hepatocellular carcinoma (HCC). In this study, we prepared a Bispecific T cell engager (BiTE) targeting Glypican 3 (GPC3) and CD3. The GPC3/CD3 BiTE was prepared by fusing the single-chain variable fragment (scFv) of the humanized anti-GPC3 antibody...

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Detalles Bibliográficos
Autores principales: Bi, Yanyu, Jiang, Hua, Wang, Peng, Song, Bo, Wang, Huamao, Kong, Xianming, Li, Zonghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581077/
https://www.ncbi.nlm.nih.gov/pubmed/28881778
http://dx.doi.org/10.18632/oncotarget.17905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581077/
https://www.ncbi.nlm.nih.gov/pubmed/28881778
http://dx.doi.org/10.18632/oncotarget.17905

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