Cargando…

MicroRNA profiles involved in trifluridine resistance

Trifluridine (FTD) is a key component of the novel oral antitumor drug trifluridine/tipiracil, which is approved for the treatment of patients with metastatic colorectal cancer refractory to standard chemotherapies. A microRNA analysis of three colorectal cell lines was conducted to investigate caus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsunekuni, Kenta, Konno, Masamitsu, Asai, Ayumu, Koseki, Jun, Kobunai, Takashi, Takechi, Teiji, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581089/ https://www.ncbi.nlm.nih.gov/pubmed/28881790 http://dx.doi.org/10.18632/oncotarget.18078

Ejemplares similares

CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure
por: Tsunekuni, Kenta, et al.
Publicado: (2019)

Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA
por: Koseki, Jun, et al.
Publicado: (2020)

Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression
por: Matsuoka, Kazuaki, et al.
Publicado: (2018)

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2
por: Asai, Ayumu, et al.
Publicado: (2018)

Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer
por: Colvin, Hugh, et al.
Publicado: (2016)

Distinct methylation levels of mature microRNAs in gastrointestinal cancers
por: Konno, Masamitsu, et al.
Publicado: (2019)

Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells
por: Konno, Masamitsu, et al.
Publicado: (2018)

Mitochondrial pyruvate carrier 1 expression controls cancer epithelial‐mesenchymal transition and radioresistance
por: Takaoka, Yuji, et al.
Publicado: (2019)

Hereditary pancreatitis model by blastocyst complementation in mouse
por: Asai, Ayumu, et al.
Publicado: (2020)

Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis
por: Koseki, Jun, et al.
Publicado: (2018)

Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming
por: Konno, Masamitsu, et al.
Publicado: (2015)

A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells
por: Koseki, Jun, et al.
Publicado: (2016)

Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution
por: Ohshiro, Takahito, et al.
Publicado: (2019)

MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells
por: Ogawa, Hisataka, et al.
Publicado: (2015)

Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells
por: Tamari, Keisuke, et al.
Publicado: (2018)

Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2′-Deoxyuridine in Colorectal Cancer Cell Lines
por: Tsukihara, Hiroshi, et al.
Publicado: (2016)

Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma
por: Matsushita, Katsunori, et al.
Publicado: (2021)

State-of-the-Art Technology of Model Organisms for Current Human Medicine
por: Konno, Masamitsu, et al.
Publicado: (2020)

Single-molecule RNA sequencing for simultaneous detection of m6A and 5mC
por: Ohshiro, Takahito, et al.
Publicado: (2021)

Susceptibility of pancreatic cancer stem cells to reprogramming
por: Noguchi, Kozo, et al.
Publicado: (2015)

Computational analyses for cancer biology based on exhaustive experimental backgrounds
por: Koseki, Jun, et al.
Publicado: (2019)

Oncogene c-Myc promotes epitranscriptome m(6)A reader YTHDF1 expression in colorectal cancer
por: Nishizawa, Yujiro, et al.
Publicado: (2017)

Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer
por: Suzuki, Norihiko, et al.
Publicado: (2017)

Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer
por: Suzuki, Norihiko, et al.
Publicado: (2021)

Computational healthcare: Present and future perspectives (Review)
por: Asai, Ayumu, et al.
Publicado: (2021)

Perspective beyond Cancer Genomics: Bioenergetics of Cancer Stem Cells
por: Ishii, Hideshi, et al.
Publicado: (2010)

A Four-Dimensional Organoid System to Visualize Cancer Cell Vascular Invasion
por: Yanagisawa, Kiminori, et al.
Publicado: (2020)

Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis
por: Hamabe, Atsushi, et al.
Publicado: (2014)

Effective Sequential Combined Chemotherapy with Trifluridine/Tipiracil and Regorafenib in Human Colorectal Cancer Cells
por: Matsuoka, Kazuaki, et al.
Publicado: (2018)

Convolutional Neural Network Can Recognize Drug Resistance of Single Cancer Cells
por: Yanagisawa, Kiminori, et al.
Publicado: (2020)

Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice
por: Ueda, Yuji, et al.
Publicado: (2019)

MicroRNA Processing and Human Cancer
por: Ohtsuka, Masahisa, et al.
Publicado: (2015)

COVID-19 Drug Discovery Using Intensive Approaches
por: Asai, Ayumu, et al.
Publicado: (2020)

Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts
por: Suzuki, Norihiko, et al.
Publicado: (2016)

Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells
por: Konno, Masamitsu, et al.
Publicado: (2015)

Scent test using Caenorhabditis elegans to screen for early-stage pancreatic cancer
por: Asai, Ayumu, et al.
Publicado: (2021)

Direct observation of DNA alterations induced by a DNA disruptor
por: Ohshiro, Takahito, et al.
Publicado: (2022)

AI for medical use
por: Konno, Masamitsu, et al.
Publicado: (2019)

BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells
por: Sueda, Toshinori, et al.
Publicado: (2016)

Immuno-Surgical Management of Pancreatic Cancer with Analysis of Cancer Exosomes
por: Takeda, Yu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_arh0hbem0dcm80nnib1aa02fk1