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Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling
Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581149/ https://www.ncbi.nlm.nih.gov/pubmed/28881850 http://dx.doi.org/10.18632/oncotarget.17255 |
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author | Ma, Yuan Zou, Hai Zhu, Xing-Xing Pang, Jie Xu, Qiang Jin, Qin-Yang Ding, Ya-Hui Zhou, Bing Huang, Dong-Sheng |
author_facet | Ma, Yuan Zou, Hai Zhu, Xing-Xing Pang, Jie Xu, Qiang Jin, Qin-Yang Ding, Ya-Hui Zhou, Bing Huang, Dong-Sheng |
author_sort | Ma, Yuan |
collection | PubMed |
description | Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular remodeling (VR). Numerous studies have highlighted a crucial role of TGF-β in VR and suggest potential therapeutic targets of the TGF-β signaling pathways for VR. Changes in TGF-β activity may elicit anti-VR activity and may serve as a novel therapeutic target for VR therapy. This review we discusses the smad-dependent signaling pathway, such as TGF-β/Smads, TGF-β/Sirtuins, TGF-β/BMP, TGF-β/miRNAs, TGF-β/MAPK, and Smad-independent signaling pathway of TGF-β, such as TGF-β/PI3K/Akt, TGF-β/Rho/ROCK,TGF-β/Wnt/β-catenin in the cardiac fibrosis and subsequent progression of VR. Furthermore, agonists and antagonists of TGF-β as potential therapeutic targets in VR are also described. |
format | Online Article Text |
id | pubmed-5581149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55811492017-09-06 Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling Ma, Yuan Zou, Hai Zhu, Xing-Xing Pang, Jie Xu, Qiang Jin, Qin-Yang Ding, Ya-Hui Zhou, Bing Huang, Dong-Sheng Oncotarget Review Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular remodeling (VR). Numerous studies have highlighted a crucial role of TGF-β in VR and suggest potential therapeutic targets of the TGF-β signaling pathways for VR. Changes in TGF-β activity may elicit anti-VR activity and may serve as a novel therapeutic target for VR therapy. This review we discusses the smad-dependent signaling pathway, such as TGF-β/Smads, TGF-β/Sirtuins, TGF-β/BMP, TGF-β/miRNAs, TGF-β/MAPK, and Smad-independent signaling pathway of TGF-β, such as TGF-β/PI3K/Akt, TGF-β/Rho/ROCK,TGF-β/Wnt/β-catenin in the cardiac fibrosis and subsequent progression of VR. Furthermore, agonists and antagonists of TGF-β as potential therapeutic targets in VR are also described. Impact Journals LLC 2017-04-19 /pmc/articles/PMC5581149/ /pubmed/28881850 http://dx.doi.org/10.18632/oncotarget.17255 Text en Copyright: © 2017 Ma et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Review Ma, Yuan Zou, Hai Zhu, Xing-Xing Pang, Jie Xu, Qiang Jin, Qin-Yang Ding, Ya-Hui Zhou, Bing Huang, Dong-Sheng Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling |
title | Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling |
title_full | Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling |
title_fullStr | Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling |
title_full_unstemmed | Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling |
title_short | Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling |
title_sort | transforming growth factor β: a potential biomarker and therapeutic target of ventricular remodeling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581149/ https://www.ncbi.nlm.nih.gov/pubmed/28881850 http://dx.doi.org/10.18632/oncotarget.17255 |
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