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Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling

Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the...

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Autores principales: Ma, Yuan, Zou, Hai, Zhu, Xing-Xing, Pang, Jie, Xu, Qiang, Jin, Qin-Yang, Ding, Ya-Hui, Zhou, Bing, Huang, Dong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581149/
https://www.ncbi.nlm.nih.gov/pubmed/28881850
http://dx.doi.org/10.18632/oncotarget.17255
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author Ma, Yuan
Zou, Hai
Zhu, Xing-Xing
Pang, Jie
Xu, Qiang
Jin, Qin-Yang
Ding, Ya-Hui
Zhou, Bing
Huang, Dong-Sheng
author_facet Ma, Yuan
Zou, Hai
Zhu, Xing-Xing
Pang, Jie
Xu, Qiang
Jin, Qin-Yang
Ding, Ya-Hui
Zhou, Bing
Huang, Dong-Sheng
author_sort Ma, Yuan
collection PubMed
description Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular remodeling (VR). Numerous studies have highlighted a crucial role of TGF-β in VR and suggest potential therapeutic targets of the TGF-β signaling pathways for VR. Changes in TGF-β activity may elicit anti-VR activity and may serve as a novel therapeutic target for VR therapy. This review we discusses the smad-dependent signaling pathway, such as TGF-β/Smads, TGF-β/Sirtuins, TGF-β/BMP, TGF-β/miRNAs, TGF-β/MAPK, and Smad-independent signaling pathway of TGF-β, such as TGF-β/PI3K/Akt, TGF-β/Rho/ROCK,TGF-β/Wnt/β-catenin in the cardiac fibrosis and subsequent progression of VR. Furthermore, agonists and antagonists of TGF-β as potential therapeutic targets in VR are also described.
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spelling pubmed-55811492017-09-06 Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling Ma, Yuan Zou, Hai Zhu, Xing-Xing Pang, Jie Xu, Qiang Jin, Qin-Yang Ding, Ya-Hui Zhou, Bing Huang, Dong-Sheng Oncotarget Review Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular remodeling (VR). Numerous studies have highlighted a crucial role of TGF-β in VR and suggest potential therapeutic targets of the TGF-β signaling pathways for VR. Changes in TGF-β activity may elicit anti-VR activity and may serve as a novel therapeutic target for VR therapy. This review we discusses the smad-dependent signaling pathway, such as TGF-β/Smads, TGF-β/Sirtuins, TGF-β/BMP, TGF-β/miRNAs, TGF-β/MAPK, and Smad-independent signaling pathway of TGF-β, such as TGF-β/PI3K/Akt, TGF-β/Rho/ROCK,TGF-β/Wnt/β-catenin in the cardiac fibrosis and subsequent progression of VR. Furthermore, agonists and antagonists of TGF-β as potential therapeutic targets in VR are also described. Impact Journals LLC 2017-04-19 /pmc/articles/PMC5581149/ /pubmed/28881850 http://dx.doi.org/10.18632/oncotarget.17255 Text en Copyright: © 2017 Ma et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Ma, Yuan
Zou, Hai
Zhu, Xing-Xing
Pang, Jie
Xu, Qiang
Jin, Qin-Yang
Ding, Ya-Hui
Zhou, Bing
Huang, Dong-Sheng
Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling
title Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling
title_full Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling
title_fullStr Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling
title_full_unstemmed Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling
title_short Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling
title_sort transforming growth factor β: a potential biomarker and therapeutic target of ventricular remodeling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581149/
https://www.ncbi.nlm.nih.gov/pubmed/28881850
http://dx.doi.org/10.18632/oncotarget.17255
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