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Succinate: An initiator in tumorigenesis and progression
As an intermediate metabolite of the tricarboxylic acid cycle in mitochondria, succinate is widely investigated for its role in metabolism. In recent years, an increasing number of studies have concentrated on the unanticipated role of succinate outside metabolism, acting as, for instance, an inflam...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581152/ https://www.ncbi.nlm.nih.gov/pubmed/28881853 http://dx.doi.org/10.18632/oncotarget.17734 |
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author | Zhao, Ting Mu, Xianmin You, Qiang |
author_facet | Zhao, Ting Mu, Xianmin You, Qiang |
author_sort | Zhao, Ting |
collection | PubMed |
description | As an intermediate metabolite of the tricarboxylic acid cycle in mitochondria, succinate is widely investigated for its role in metabolism. In recent years, an increasing number of studies have concentrated on the unanticipated role of succinate outside metabolism, acting as, for instance, an inflammatory signal or a carcinogenic initiator. Actually, succinate dehydrogenase gene mutations and abnormal succinate accumulation have been observed in a battery of hereditary and sporadic malignancies. In this review, we discuss the unexpected role of succinate and possible mechanisms that may contribute to its accumulation. Additionally, we describe how the high concentration of succinate in the tumor microenvironment acts as an active participant in tumorigenesis, rather than a passive bystander or innocent victim. Focusing on mechanism-based research, we summarize some targeted therapies which have been applied to the clinic or are currently under development. Furthermore, we posit that investigational drugs with different molecular targets may expand our horizon in anticancer therapy. |
format | Online Article Text |
id | pubmed-5581152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55811522017-09-06 Succinate: An initiator in tumorigenesis and progression Zhao, Ting Mu, Xianmin You, Qiang Oncotarget Review As an intermediate metabolite of the tricarboxylic acid cycle in mitochondria, succinate is widely investigated for its role in metabolism. In recent years, an increasing number of studies have concentrated on the unanticipated role of succinate outside metabolism, acting as, for instance, an inflammatory signal or a carcinogenic initiator. Actually, succinate dehydrogenase gene mutations and abnormal succinate accumulation have been observed in a battery of hereditary and sporadic malignancies. In this review, we discuss the unexpected role of succinate and possible mechanisms that may contribute to its accumulation. Additionally, we describe how the high concentration of succinate in the tumor microenvironment acts as an active participant in tumorigenesis, rather than a passive bystander or innocent victim. Focusing on mechanism-based research, we summarize some targeted therapies which have been applied to the clinic or are currently under development. Furthermore, we posit that investigational drugs with different molecular targets may expand our horizon in anticancer therapy. Impact Journals LLC 2017-05-10 /pmc/articles/PMC5581152/ /pubmed/28881853 http://dx.doi.org/10.18632/oncotarget.17734 Text en Copyright: © 2017 Zhao et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Review Zhao, Ting Mu, Xianmin You, Qiang Succinate: An initiator in tumorigenesis and progression |
title | Succinate: An initiator in tumorigenesis and progression |
title_full | Succinate: An initiator in tumorigenesis and progression |
title_fullStr | Succinate: An initiator in tumorigenesis and progression |
title_full_unstemmed | Succinate: An initiator in tumorigenesis and progression |
title_short | Succinate: An initiator in tumorigenesis and progression |
title_sort | succinate: an initiator in tumorigenesis and progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581152/ https://www.ncbi.nlm.nih.gov/pubmed/28881853 http://dx.doi.org/10.18632/oncotarget.17734 |
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