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Behavioral Changes in Patients with Multiple Sclerosis
BACKGROUND: Behavioral changes are common in patients with multiple sclerosis (MS), however not as readily recognized as cognitive impairments. OBJECTIVE: The aim of this study was to analyze behavioral changes and its relation to disease characteristics, disability, and cognitive impairments in pat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581390/ https://www.ncbi.nlm.nih.gov/pubmed/28894432 http://dx.doi.org/10.3389/fneur.2017.00437 |
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author | Heldner, Mirjam R. Kaufmann-Ezra, Sigal Gutbrod, Klemens Bernasconi, Corrado Bigi, Sandra Blatter, Verena Mattle, Heinrich P. Müri, René M. Verma, Rajeev K. Kamm, Christian P. |
author_facet | Heldner, Mirjam R. Kaufmann-Ezra, Sigal Gutbrod, Klemens Bernasconi, Corrado Bigi, Sandra Blatter, Verena Mattle, Heinrich P. Müri, René M. Verma, Rajeev K. Kamm, Christian P. |
author_sort | Heldner, Mirjam R. |
collection | PubMed |
description | BACKGROUND: Behavioral changes are common in patients with multiple sclerosis (MS), however not as readily recognized as cognitive impairments. OBJECTIVE: The aim of this study was to analyze behavioral changes and its relation to disease characteristics, disability, and cognitive impairments in patients with MS. METHOD: This is a single-center cross-sectional study. A detailed neuropsychological examination, including the Frontal Systems Behavior Scale (FrSBe), the Beck depression inventory (BDI), and the Wuerzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS) test, was performed. FrSBe results were correlated with disease characteristics, disability, and cognitive assessments. RESULTS: 66 patients were enrolled (mean age: 43.4 years; disease duration: 9.3 years; Expanded Disability Status Scale: 3.0). Up to one third of patients showed behavioral changes in at least one domain or the total score of the FrSBe. Patients were mildly affected with regard to cognitive functioning. Consistent correlation was found between behavioral changes and fatigue (WEIMuS) and depressive symptoms (BDI), but not with disease characteristics, disability, or cognitive functions. There was an increase of behavioral changes on all FrSBe scales in the current status compared to the retrospectively rated status before disease onset. Self- and family ratings with regard to current behavioral changes were similar. CONCLUSION: Behavioral changes are common in otherwise mildly affected MS patients with up to one third being affected. In this patient cohort, behavioral changes occur largely independent of disease characteristics, physical disability, and cognitive functioning but correlate with both fatigue and depressive symptoms. Therefore, they should be tested specifically. |
format | Online Article Text |
id | pubmed-5581390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55813902017-09-11 Behavioral Changes in Patients with Multiple Sclerosis Heldner, Mirjam R. Kaufmann-Ezra, Sigal Gutbrod, Klemens Bernasconi, Corrado Bigi, Sandra Blatter, Verena Mattle, Heinrich P. Müri, René M. Verma, Rajeev K. Kamm, Christian P. Front Neurol Neuroscience BACKGROUND: Behavioral changes are common in patients with multiple sclerosis (MS), however not as readily recognized as cognitive impairments. OBJECTIVE: The aim of this study was to analyze behavioral changes and its relation to disease characteristics, disability, and cognitive impairments in patients with MS. METHOD: This is a single-center cross-sectional study. A detailed neuropsychological examination, including the Frontal Systems Behavior Scale (FrSBe), the Beck depression inventory (BDI), and the Wuerzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS) test, was performed. FrSBe results were correlated with disease characteristics, disability, and cognitive assessments. RESULTS: 66 patients were enrolled (mean age: 43.4 years; disease duration: 9.3 years; Expanded Disability Status Scale: 3.0). Up to one third of patients showed behavioral changes in at least one domain or the total score of the FrSBe. Patients were mildly affected with regard to cognitive functioning. Consistent correlation was found between behavioral changes and fatigue (WEIMuS) and depressive symptoms (BDI), but not with disease characteristics, disability, or cognitive functions. There was an increase of behavioral changes on all FrSBe scales in the current status compared to the retrospectively rated status before disease onset. Self- and family ratings with regard to current behavioral changes were similar. CONCLUSION: Behavioral changes are common in otherwise mildly affected MS patients with up to one third being affected. In this patient cohort, behavioral changes occur largely independent of disease characteristics, physical disability, and cognitive functioning but correlate with both fatigue and depressive symptoms. Therefore, they should be tested specifically. Frontiers Media S.A. 2017-08-28 /pmc/articles/PMC5581390/ /pubmed/28894432 http://dx.doi.org/10.3389/fneur.2017.00437 Text en Copyright © 2017 Heldner, Kaufmann-Ezra, Gutbrod, Bernasconi, Bigi, Blatter, Mattle, Müri, Verma and Kamm. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Heldner, Mirjam R. Kaufmann-Ezra, Sigal Gutbrod, Klemens Bernasconi, Corrado Bigi, Sandra Blatter, Verena Mattle, Heinrich P. Müri, René M. Verma, Rajeev K. Kamm, Christian P. Behavioral Changes in Patients with Multiple Sclerosis |
title | Behavioral Changes in Patients with Multiple Sclerosis |
title_full | Behavioral Changes in Patients with Multiple Sclerosis |
title_fullStr | Behavioral Changes in Patients with Multiple Sclerosis |
title_full_unstemmed | Behavioral Changes in Patients with Multiple Sclerosis |
title_short | Behavioral Changes in Patients with Multiple Sclerosis |
title_sort | behavioral changes in patients with multiple sclerosis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581390/ https://www.ncbi.nlm.nih.gov/pubmed/28894432 http://dx.doi.org/10.3389/fneur.2017.00437 |
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