Pathobiology of the 129:Stat1(−/−) mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype

BACKGROUND: Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1 (tm1Rds)) develop estrogen receptor-positive (ER(+)), luminal-type mammary carcinomas at an advanced age. There is evidence for both host environment as well as tumor cell-intrinsic mechanisms to initiate tumorigenesis in this model....

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Detalles Bibliográficos
Autores principales: Mori, Hidetoshi, Chen, Jane Q., Cardiff, Robert D., Pénzváltó, Zsófia, Hubbard, Neil E., Schuetter, Louis, Hovey, Russell C., Trott, Josephine F., Borowsky, Alexander D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581425/
https://www.ncbi.nlm.nih.gov/pubmed/28865492
http://dx.doi.org/10.1186/s13058-017-0892-8

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