Cargando…
Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants
BACKGROUND: Lithium augmentation of antidepressants is an effective strategy in treatment-resistant depression. The proteohormone ghrelin is thought to be involved in the pathophysiology of depression. The purpose of this study was to investigate the association of treatment response with the course...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581484/ https://www.ncbi.nlm.nih.gov/pubmed/28911006 http://dx.doi.org/10.1093/ijnp/pyw082 |
_version_ | 1783261058963603456 |
---|---|
author | Ricken, Roland Bopp, Sandra Schlattmann, Peter Himmerich, Hubertus Bschor, Tom Richter, Christoph Elstner, Samuel Stamm, Thomas J Schulz-Ratei, Brigitte Lingesleben, Alexandra Reischies, Friedel M Sterzer, Philipp Borgwardt, Stefan Bauer, Michael Heinz, Andreas Hellweg, Rainer Lang, Undine E Adli, Mazda |
author_facet | Ricken, Roland Bopp, Sandra Schlattmann, Peter Himmerich, Hubertus Bschor, Tom Richter, Christoph Elstner, Samuel Stamm, Thomas J Schulz-Ratei, Brigitte Lingesleben, Alexandra Reischies, Friedel M Sterzer, Philipp Borgwardt, Stefan Bauer, Michael Heinz, Andreas Hellweg, Rainer Lang, Undine E Adli, Mazda |
author_sort | Ricken, Roland |
collection | PubMed |
description | BACKGROUND: Lithium augmentation of antidepressants is an effective strategy in treatment-resistant depression. The proteohormone ghrelin is thought to be involved in the pathophysiology of depression. The purpose of this study was to investigate the association of treatment response with the course of ghrelin levels during lithium augmentation. METHOD: Ghrelin serum concentrations and severity of depression were measured in 85 acute depressive patients before and after 4 weeks of lithium augmentation. RESULTS: In a linear mixed model analysis, we found a significant effect of response*time interaction (F(1.81)=9.48; P=.0028): under treatment, ghrelin levels increased in nonresponders and slightly decreased in responders to lithium augmentation. The covariate female gender had a significant positive effect (F(1.83)=4.69; P=.033), whereas time, response, appetite, and body mass index (kg/m(2)) did not show any significant effect on ghrelin levels (P>.05). CONCLUSION: This is the first study showing that the course of ghrelin levels separates responders and nonresponders to lithium augmentation. Present results support the hypothesis that ghrelin serum concentrations might be involved in response to pharmacological treatment of depression. |
format | Online Article Text |
id | pubmed-5581484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55814842017-09-06 Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants Ricken, Roland Bopp, Sandra Schlattmann, Peter Himmerich, Hubertus Bschor, Tom Richter, Christoph Elstner, Samuel Stamm, Thomas J Schulz-Ratei, Brigitte Lingesleben, Alexandra Reischies, Friedel M Sterzer, Philipp Borgwardt, Stefan Bauer, Michael Heinz, Andreas Hellweg, Rainer Lang, Undine E Adli, Mazda Int J Neuropsychopharmacol Brief Report BACKGROUND: Lithium augmentation of antidepressants is an effective strategy in treatment-resistant depression. The proteohormone ghrelin is thought to be involved in the pathophysiology of depression. The purpose of this study was to investigate the association of treatment response with the course of ghrelin levels during lithium augmentation. METHOD: Ghrelin serum concentrations and severity of depression were measured in 85 acute depressive patients before and after 4 weeks of lithium augmentation. RESULTS: In a linear mixed model analysis, we found a significant effect of response*time interaction (F(1.81)=9.48; P=.0028): under treatment, ghrelin levels increased in nonresponders and slightly decreased in responders to lithium augmentation. The covariate female gender had a significant positive effect (F(1.83)=4.69; P=.033), whereas time, response, appetite, and body mass index (kg/m(2)) did not show any significant effect on ghrelin levels (P>.05). CONCLUSION: This is the first study showing that the course of ghrelin levels separates responders and nonresponders to lithium augmentation. Present results support the hypothesis that ghrelin serum concentrations might be involved in response to pharmacological treatment of depression. Oxford University Press 2017-07-22 /pmc/articles/PMC5581484/ /pubmed/28911006 http://dx.doi.org/10.1093/ijnp/pyw082 Text en © The Author 2017. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Brief Report Ricken, Roland Bopp, Sandra Schlattmann, Peter Himmerich, Hubertus Bschor, Tom Richter, Christoph Elstner, Samuel Stamm, Thomas J Schulz-Ratei, Brigitte Lingesleben, Alexandra Reischies, Friedel M Sterzer, Philipp Borgwardt, Stefan Bauer, Michael Heinz, Andreas Hellweg, Rainer Lang, Undine E Adli, Mazda Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants |
title | Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants |
title_full | Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants |
title_fullStr | Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants |
title_full_unstemmed | Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants |
title_short | Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants |
title_sort | ghrelin serum concentrations are associated with treatment response during lithium augmentation of antidepressants |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581484/ https://www.ncbi.nlm.nih.gov/pubmed/28911006 http://dx.doi.org/10.1093/ijnp/pyw082 |
work_keys_str_mv | AT rickenroland ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT boppsandra ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT schlattmannpeter ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT himmerichhubertus ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT bschortom ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT richterchristoph ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT elstnersamuel ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT stammthomasj ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT schulzrateibrigitte ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT lingeslebenalexandra ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT reischiesfriedelm ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT sterzerphilipp ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT borgwardtstefan ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT bauermichael ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT heinzandreas ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT hellwegrainer ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT langundinee ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants AT adlimazda ghrelinserumconcentrationsareassociatedwithtreatmentresponseduringlithiumaugmentationofantidepressants |