Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting the upper and lower motor neurons in the motor cortex and spinal cord. Abnormal accumulation of mutant superoxide dismutase I (SOD1) in motor neurons is a pathological hallmark of some forms of the disease. We have sh...

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Detalles Bibliográficos
Autores principales: Chen, Liyu, Watson, Clare, Morsch, Marco, Cole, Nicholas J., Chung, Roger S., Saunders, Darren N., Yerbury, Justin J., Vine, Kara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582160/
https://www.ncbi.nlm.nih.gov/pubmed/28912673
http://dx.doi.org/10.3389/fnins.2017.00476

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