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Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation

Creatine (Cr), phosphocreatine (PCr), and creatine kinases (CK) comprise an energy shuttle linking ATP production in mitochondria with cellular consumption sites. Myocytes cannot synthesize Cr: these cells depend on uptake across the cell membrane by a specialized creatine transporter (CrT) to maint...

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Detalles Bibliográficos
Autores principales:	Santacruz, Lucia, Arciniegas, Antonio Jose Luis, Darrabie, Marcus, Mantilla, Jose G., Baron, Rebecca M., Bowles, Dawn E., Mishra, Rajashree, Jacobs, Danny O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582266/ https://www.ncbi.nlm.nih.gov/pubmed/28821596 http://dx.doi.org/10.14814/phy2.13382

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