Small nucleoli are a cellular hallmark of longevity

Animal lifespan is regulated by conserved metabolic signalling pathways and specific transcription factors, but whether these pathways affect common downstream mechanisms remains largely elusive. Here we show that NCL-1/TRIM2/Brat tumour suppressor extends lifespan and limits nucleolar size in the m...

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Detalles Bibliográficos
Autores principales: Tiku, Varnesh, Jain, Chirag, Raz, Yotam, Nakamura, Shuhei, Heestand, Bree, Liu, Wei, Späth, Martin, Suchiman, H. Eka. D., Müller, Roman-Ulrich, Slagboom, P. Eline, Partridge, Linda, Antebi, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582349/
https://www.ncbi.nlm.nih.gov/pubmed/28853436
http://dx.doi.org/10.1038/ncomms16083

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