Cargando…
The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients
BACKGROUND: The purpose of this study was to investigate the effects of an 8-week aerobic exercise and supplementation of 25(OH)D3 on GLP1 and DDP4 levels in men with type II diabetes. METHODS: In this semiexperimental research, among 40–60-year-old men with type II diabetes who were referred to the...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582496/ https://www.ncbi.nlm.nih.gov/pubmed/28900535 http://dx.doi.org/10.4103/ijpvm.IJPVM_161_17 |
_version_ | 1783261198176747520 |
---|---|
author | Rahimi, Naser Samavati Sharif, Mohammad Ali Goharian, Amir Reza Pour, Ali Heidarian |
author_facet | Rahimi, Naser Samavati Sharif, Mohammad Ali Goharian, Amir Reza Pour, Ali Heidarian |
author_sort | Rahimi, Naser |
collection | PubMed |
description | BACKGROUND: The purpose of this study was to investigate the effects of an 8-week aerobic exercise and supplementation of 25(OH)D3 on GLP1 and DDP4 levels in men with type II diabetes. METHODS: In this semiexperimental research, among 40–60-year-old men with type II diabetes who were referred to the diabetic center of Isabn-E Maryam hospital in Isfahan; of whom, 48 patients were voluntarily accepted and then were randomly divided into 4 groups: aerobic exercise group, aerobic exercise with 25(OH) D supplement group, 25(OH) D supplement group, and the control group. An aerobic exercise program was conducted for 8 weeks (3 sessions/week, each session 60 to75 min with 60–80% HRmax). The supplement user group received 50,000 units of oral Vitamin D once weekly for 8 weeks. The GLP1, DPP4, and 25(OH) D levels were measured before and after the intervention. At last, the data were statistically analyzed using the ANCOVA and post hoc test of least significant difference. RESULTS: The results of ANCOVA showed a significant difference between the GLP1 and DPP4 levels in aerobic exercise with control group while these changes were not statistically significant between the 25(OH) D supplement group with control group (P < 0.05). CONCLUSIONS: Aerobic exercises have resulted an increase in GLP1 level and a decrease in DPP4 level. However, consumption of Vitamin D supplement alone did not cause any changes in GLP1and DPP4 levels but led to an increase in 25-hydroxy Vitamin D level. |
format | Online Article Text |
id | pubmed-5582496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55824962017-09-12 The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients Rahimi, Naser Samavati Sharif, Mohammad Ali Goharian, Amir Reza Pour, Ali Heidarian Int J Prev Med Original Article BACKGROUND: The purpose of this study was to investigate the effects of an 8-week aerobic exercise and supplementation of 25(OH)D3 on GLP1 and DDP4 levels in men with type II diabetes. METHODS: In this semiexperimental research, among 40–60-year-old men with type II diabetes who were referred to the diabetic center of Isabn-E Maryam hospital in Isfahan; of whom, 48 patients were voluntarily accepted and then were randomly divided into 4 groups: aerobic exercise group, aerobic exercise with 25(OH) D supplement group, 25(OH) D supplement group, and the control group. An aerobic exercise program was conducted for 8 weeks (3 sessions/week, each session 60 to75 min with 60–80% HRmax). The supplement user group received 50,000 units of oral Vitamin D once weekly for 8 weeks. The GLP1, DPP4, and 25(OH) D levels were measured before and after the intervention. At last, the data were statistically analyzed using the ANCOVA and post hoc test of least significant difference. RESULTS: The results of ANCOVA showed a significant difference between the GLP1 and DPP4 levels in aerobic exercise with control group while these changes were not statistically significant between the 25(OH) D supplement group with control group (P < 0.05). CONCLUSIONS: Aerobic exercises have resulted an increase in GLP1 level and a decrease in DPP4 level. However, consumption of Vitamin D supplement alone did not cause any changes in GLP1and DPP4 levels but led to an increase in 25-hydroxy Vitamin D level. Medknow Publications & Media Pvt Ltd 2017-08-08 /pmc/articles/PMC5582496/ /pubmed/28900535 http://dx.doi.org/10.4103/ijpvm.IJPVM_161_17 Text en Copyright: © 2017 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Rahimi, Naser Samavati Sharif, Mohammad Ali Goharian, Amir Reza Pour, Ali Heidarian The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients |
title | The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients |
title_full | The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients |
title_fullStr | The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients |
title_full_unstemmed | The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients |
title_short | The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients |
title_sort | effects of aerobic exercises and 25(oh) d supplementation on glp1 and dpp4 level in type ii diabetic patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582496/ https://www.ncbi.nlm.nih.gov/pubmed/28900535 http://dx.doi.org/10.4103/ijpvm.IJPVM_161_17 |
work_keys_str_mv | AT rahiminaser theeffectsofaerobicexercisesand25ohdsupplementationonglp1anddpp4levelintypeiidiabeticpatients AT samavatisharifmohammadali theeffectsofaerobicexercisesand25ohdsupplementationonglp1anddpp4levelintypeiidiabeticpatients AT goharianamirreza theeffectsofaerobicexercisesand25ohdsupplementationonglp1anddpp4levelintypeiidiabeticpatients AT pouraliheidarian theeffectsofaerobicexercisesand25ohdsupplementationonglp1anddpp4levelintypeiidiabeticpatients AT rahiminaser effectsofaerobicexercisesand25ohdsupplementationonglp1anddpp4levelintypeiidiabeticpatients AT samavatisharifmohammadali effectsofaerobicexercisesand25ohdsupplementationonglp1anddpp4levelintypeiidiabeticpatients AT goharianamirreza effectsofaerobicexercisesand25ohdsupplementationonglp1anddpp4levelintypeiidiabeticpatients AT pouraliheidarian effectsofaerobicexercisesand25ohdsupplementationonglp1anddpp4levelintypeiidiabeticpatients |