Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report

A 65-year-old woman visited our hospital due to right chest pain and dyspnea on exertion. Chest radiography revealed decreased permeability of the right lung. Computed tomography demonstrated a huge mass in the right upper lobe and right pleural effusion. Right pleural effusion cytology yielded a di...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishimura, Jun, Miyamoto, Yosuke, Fujimoto, Nobukazu, Ozeki, Taichi, Takada, Kenji, Asano, Michiko, Fuchimoto, Yasuko, Wada, Sae, Ozaki, Shinji, Kishimoto, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582498/
https://www.ncbi.nlm.nih.gov/pubmed/28878647
http://dx.doi.org/10.1159/000479147
_version_ 1783261198420017152
author Nishimura, Jun
Miyamoto, Yosuke
Fujimoto, Nobukazu
Ozeki, Taichi
Takada, Kenji
Asano, Michiko
Fuchimoto, Yasuko
Wada, Sae
Ozaki, Shinji
Kishimoto, Takumi
author_facet Nishimura, Jun
Miyamoto, Yosuke
Fujimoto, Nobukazu
Ozeki, Taichi
Takada, Kenji
Asano, Michiko
Fuchimoto, Yasuko
Wada, Sae
Ozaki, Shinji
Kishimoto, Takumi
author_sort Nishimura, Jun
collection PubMed
description A 65-year-old woman visited our hospital due to right chest pain and dyspnea on exertion. Chest radiography revealed decreased permeability of the right lung. Computed tomography demonstrated a huge mass in the right upper lobe and right pleural effusion. Right pleural effusion cytology yielded a diagnosis of adenocarcinoma and was positive for mutation of epidermal growth factor receptor (EGFR; exon 21 L858R). Afatinib was selected for the initial treatment. Multiple tumors regressed remarkably, but then rapidly progressed 3 months later. We performed re-biopsy to detect the mechanism of resistance to afatinib. Histopathology revealed a mixture of small cell carcinoma (SCC) and adenocarcinoma harboring same EGFR mutation. To the best of our knowledge, this is the first report of transformation to SCC after treatment with afatinib.
format Online
Article
Text
id pubmed-5582498
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-55824982017-09-06 Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report Nishimura, Jun Miyamoto, Yosuke Fujimoto, Nobukazu Ozeki, Taichi Takada, Kenji Asano, Michiko Fuchimoto, Yasuko Wada, Sae Ozaki, Shinji Kishimoto, Takumi Case Rep Oncol Case Report A 65-year-old woman visited our hospital due to right chest pain and dyspnea on exertion. Chest radiography revealed decreased permeability of the right lung. Computed tomography demonstrated a huge mass in the right upper lobe and right pleural effusion. Right pleural effusion cytology yielded a diagnosis of adenocarcinoma and was positive for mutation of epidermal growth factor receptor (EGFR; exon 21 L858R). Afatinib was selected for the initial treatment. Multiple tumors regressed remarkably, but then rapidly progressed 3 months later. We performed re-biopsy to detect the mechanism of resistance to afatinib. Histopathology revealed a mixture of small cell carcinoma (SCC) and adenocarcinoma harboring same EGFR mutation. To the best of our knowledge, this is the first report of transformation to SCC after treatment with afatinib. S. Karger AG 2017-07-21 /pmc/articles/PMC5582498/ /pubmed/28878647 http://dx.doi.org/10.1159/000479147 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Nishimura, Jun
Miyamoto, Yosuke
Fujimoto, Nobukazu
Ozeki, Taichi
Takada, Kenji
Asano, Michiko
Fuchimoto, Yasuko
Wada, Sae
Ozaki, Shinji
Kishimoto, Takumi
Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report
title Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report
title_full Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report
title_fullStr Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report
title_full_unstemmed Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report
title_short Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report
title_sort adenocarcinoma of the lung acquiring resistance to afatinib by transformation to small cell carcinoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582498/
https://www.ncbi.nlm.nih.gov/pubmed/28878647
http://dx.doi.org/10.1159/000479147
work_keys_str_mv AT nishimurajun adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT miyamotoyosuke adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT fujimotonobukazu adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT ozekitaichi adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT takadakenji adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT asanomichiko adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT fuchimotoyasuko adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT wadasae adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT ozakishinji adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport
AT kishimototakumi adenocarcinomaofthelungacquiringresistancetoafatinibbytransformationtosmallcellcarcinomaacasereport

Ejemplares similares