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Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features

Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or p...

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Autores principales: Boudaouara, Ons, Chaari, Chiraz, Hassini, Abdelkhalek, Boudaouara, Tahya Sellami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582566/
https://www.ncbi.nlm.nih.gov/pubmed/28900337
http://dx.doi.org/10.4103/ijmpo.ijmpo_115_16
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author Boudaouara, Ons
Chaari, Chiraz
Hassini, Abdelkhalek
Boudaouara, Tahya Sellami
author_facet Boudaouara, Ons
Chaari, Chiraz
Hassini, Abdelkhalek
Boudaouara, Tahya Sellami
author_sort Boudaouara, Ons
collection PubMed
description Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast. Thus, immunohistochemical staining by myofibroblastic markers is helpful for confirming diagnosis. Herein, we present a case of MFB in a 43-year-old female. This case report emphasizes the role of immunohistochemistry as gold standard in the diagnosis of MFB. This case is also being presented because of its unusual radiologic findings, its epithelioid histologic variant mimicking malignancy, and its uncommon immunohistochemical phenotype.
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spelling pubmed-55825662017-09-12 Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features Boudaouara, Ons Chaari, Chiraz Hassini, Abdelkhalek Boudaouara, Tahya Sellami Indian J Med Paediatr Oncol Case Report Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast. Thus, immunohistochemical staining by myofibroblastic markers is helpful for confirming diagnosis. Herein, we present a case of MFB in a 43-year-old female. This case report emphasizes the role of immunohistochemistry as gold standard in the diagnosis of MFB. This case is also being presented because of its unusual radiologic findings, its epithelioid histologic variant mimicking malignancy, and its uncommon immunohistochemical phenotype. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5582566/ /pubmed/28900337 http://dx.doi.org/10.4103/ijmpo.ijmpo_115_16 Text en Copyright: © 2017 Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Boudaouara, Ons
Chaari, Chiraz
Hassini, Abdelkhalek
Boudaouara, Tahya Sellami
Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features
title Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features
title_full Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features
title_fullStr Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features
title_full_unstemmed Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features
title_short Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features
title_sort mammary myofibroblastoma with unusual morphological and immunohistochemical features
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582566/
https://www.ncbi.nlm.nih.gov/pubmed/28900337
http://dx.doi.org/10.4103/ijmpo.ijmpo_115_16
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