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Changes in delta ADC reflect intracranial pressure changes in craniosynostosis

BACKGROUND: In patients with craniosynostosis, intracranial pressure (ICP) has been reported to increase even in the absence of overt symptoms. The early and non-invasive detection of intracranial hypertension is important for reducing the risk of abnormal brain development in pediatric patients. PU...

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Autores principales: Takahashi, Yuko, Hori, Masaaki, Shimoji, Kazuaki, Miyajima, Masakazu, Akiyama, Osamu, Arai, Hajime, Aoki, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582662/
https://www.ncbi.nlm.nih.gov/pubmed/28894592
http://dx.doi.org/10.1177/2058460117728535
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author Takahashi, Yuko
Hori, Masaaki
Shimoji, Kazuaki
Miyajima, Masakazu
Akiyama, Osamu
Arai, Hajime
Aoki, Shigeki
author_facet Takahashi, Yuko
Hori, Masaaki
Shimoji, Kazuaki
Miyajima, Masakazu
Akiyama, Osamu
Arai, Hajime
Aoki, Shigeki
author_sort Takahashi, Yuko
collection PubMed
description BACKGROUND: In patients with craniosynostosis, intracranial pressure (ICP) has been reported to increase even in the absence of overt symptoms. The early and non-invasive detection of intracranial hypertension is important for reducing the risk of abnormal brain development in pediatric patients. PURPOSE: To assess whether the apparent diffusion coefficient (ADC) of white matter during the cardiac cycle (ΔADC) would change after surgery to relieve ICP in children with craniosynostosis. MATERIAL AND METHODS: This prospective study included ten patients diagnosed with craniosynostosis and four normal controls. All ten patients underwent magnetic resonance (MR) examinations before and after surgical treatment. Single-shot diffusion MR imaging (MRI) triggered by an electrocardiogram was performed, with regions of interest (ROIs) placed on frontal white matter and basal ganglia. RESULTS: In all ten patients, ΔADC values after surgery were higher than those before surgery. This difference was statistically significant (Wilcoxon signed-rank test, P = 0.005). CONCLUSION: The change in ΔADC in the frontal white matter before and after surgery in patients with craniosynostosis indicates that it might reflect the change in ICP. Measurements of ΔADC could be a promising tool for non-invasive monitoring of ICP.
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spelling pubmed-55826622017-09-11 Changes in delta ADC reflect intracranial pressure changes in craniosynostosis Takahashi, Yuko Hori, Masaaki Shimoji, Kazuaki Miyajima, Masakazu Akiyama, Osamu Arai, Hajime Aoki, Shigeki Acta Radiol Open Research BACKGROUND: In patients with craniosynostosis, intracranial pressure (ICP) has been reported to increase even in the absence of overt symptoms. The early and non-invasive detection of intracranial hypertension is important for reducing the risk of abnormal brain development in pediatric patients. PURPOSE: To assess whether the apparent diffusion coefficient (ADC) of white matter during the cardiac cycle (ΔADC) would change after surgery to relieve ICP in children with craniosynostosis. MATERIAL AND METHODS: This prospective study included ten patients diagnosed with craniosynostosis and four normal controls. All ten patients underwent magnetic resonance (MR) examinations before and after surgical treatment. Single-shot diffusion MR imaging (MRI) triggered by an electrocardiogram was performed, with regions of interest (ROIs) placed on frontal white matter and basal ganglia. RESULTS: In all ten patients, ΔADC values after surgery were higher than those before surgery. This difference was statistically significant (Wilcoxon signed-rank test, P = 0.005). CONCLUSION: The change in ΔADC in the frontal white matter before and after surgery in patients with craniosynostosis indicates that it might reflect the change in ICP. Measurements of ΔADC could be a promising tool for non-invasive monitoring of ICP. SAGE Publications 2017-08-31 /pmc/articles/PMC5582662/ /pubmed/28894592 http://dx.doi.org/10.1177/2058460117728535 Text en © The Foundation Acta Radiologica 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research
Takahashi, Yuko
Hori, Masaaki
Shimoji, Kazuaki
Miyajima, Masakazu
Akiyama, Osamu
Arai, Hajime
Aoki, Shigeki
Changes in delta ADC reflect intracranial pressure changes in craniosynostosis
title Changes in delta ADC reflect intracranial pressure changes in craniosynostosis
title_full Changes in delta ADC reflect intracranial pressure changes in craniosynostosis
title_fullStr Changes in delta ADC reflect intracranial pressure changes in craniosynostosis
title_full_unstemmed Changes in delta ADC reflect intracranial pressure changes in craniosynostosis
title_short Changes in delta ADC reflect intracranial pressure changes in craniosynostosis
title_sort changes in delta adc reflect intracranial pressure changes in craniosynostosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582662/
https://www.ncbi.nlm.nih.gov/pubmed/28894592
http://dx.doi.org/10.1177/2058460117728535
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