Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis

BACKGROUND & AIMS: Lamins are nuclear intermediate filament proteins that comprise the major components of the nuclear lamina. Mutations in LMNA, which encodes lamins A/C, cause laminopathies, including lipodystrophy, cardiomyopathy, and premature aging syndromes. However, the role of lamins in...

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Detalles Bibliográficos
Autores principales: Kwan, Raymond, Brady, Graham F., Brzozowski, Maria, Weerasinghe, Sujith V., Martin, Hope, Park, Min-Jung, Brunt, Makayla J., Menon, Ram K., Tong, Xin, Yin, Lei, Stewart, Colin L., Omary, M. Bishr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582719/
https://www.ncbi.nlm.nih.gov/pubmed/28913408
http://dx.doi.org/10.1016/j.jcmgh.2017.06.005

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