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Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways

To examine the biochemical influences that may contribute to the success of gene therapy for ocular disorders, the role of versican, a vitreous component, in adenoviral-mediated transgene expression was examined. Versican is a large chondroitin sulfate-containing, hyaluronic acid-binding proteoglyca...

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Detalles Bibliográficos
Autores principales:	Akinfenwa, Patricia Y., Bond, Wesley S., Ildefonso, Cristhian J., Hurwitz, Mary Y., Hurwitz, Richard L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582833/ https://www.ncbi.nlm.nih.gov/pubmed/28684419 http://dx.doi.org/10.1074/jbc.M116.773549

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