Cargando…

Inverted stereocontrol of iridoid synthase in snapdragon

The natural product class of iridoids, found in various species of flowering plants, harbors astonishing chemical complexity. The discovery of iridoid biosynthetic genes in the medicinal plant Catharanthus roseus has provided insight into the biosynthetic origins of this class of natural product. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kries, Hajo, Kellner, Franziska, Kamileen, Mohamed Omar, O'Connor, Sarah E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582856/ https://www.ncbi.nlm.nih.gov/pubmed/28701463 http://dx.doi.org/10.1074/jbc.M117.800979

Ejemplares similares

Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry
por: Sherden, Nathaniel H., et al.
Publicado: (2018)

Structural determinants of reductive terpene cyclization in iridoid biosynthesis
por: Kries, Hajo, et al.
Publicado: (2015)

Transcriptome‐based identification and functional characterization of iridoid synthase involved in monotropein biosynthesis in blueberry
por: Lawas, Lovely Mae F., et al.
Publicado: (2023)

Energy Landscapes and Catalysis in Nitric-oxide Synthase
por: Sobolewska-Stawiarz, Anna, et al.
Publicado: (2014)

Phylogeny-Aware Chemoinformatic Analysis of Chemical Diversity in Lamiaceae Enables Iridoid Pathway Assembly and Discovery of Aucubin Synthase
por: Rodríguez-López, Carlos E., et al.
Publicado: (2022)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2
por: Trostchansky, Andrés, et al.
Publicado: (2011)

The Catalytic Architecture of Leukotriene C(4) Synthase with Two Arginine Residues
por: Saino, Hiromichi, et al.
Publicado: (2011)

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog
por: Nguyen, Suong, et al.
Publicado: (2013)

Arginine 104 Is a Key Catalytic Residue in Leukotriene C(4) Synthase
por: Rinaldo-Matthis, Agnes, et al.
Publicado: (2010)

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling
por: Crabtree, Mark J., et al.
Publicado: (2013)

Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide
por: Heine, Christian L., et al.
Publicado: (2015)

Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
por: Söderholm, Annika, et al.
Publicado: (2020)

Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species
por: Leisner, Courtney P., et al.
Publicado: (2017)

Structure and Mechanism of Human UDP-xylose Synthase: EVIDENCE FOR A PROMOTING ROLE OF SUGAR RING DISTORTION IN A THREE-STEP CATALYTIC CONVERSION OF UDP-GLUCURONIC ACID
por: Eixelsberger, Thomas, et al.
Publicado: (2012)

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION
por: Benson, Matthew A., et al.
Publicado: (2013)

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1
por: Chenge, Jude T., et al.
Publicado: (2017)

Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia
por: Dong, Qian, et al.
Publicado: (2015)

Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis
por: Seeliger, Jessica C., et al.
Publicado: (2012)

Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms
por: Heissler, Sarah M., et al.
Publicado: (2011)

Cellobiohydrolase Hydrolyzes Crystalline Cellulose on Hydrophobic Faces
por: Liu, Yu-San, et al.
Publicado: (2011)

Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches
por: Jeffreys, Laura N., et al.
Publicado: (2020)

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleT(JE)
por: Matthews, Sarah, et al.
Publicado: (2017)

(19)F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2
por: Ruben, Eliza A., et al.
Publicado: (2020)

Human UTY(KDM6C) Is a Male-specific N(ϵ)-Methyl Lysyl Demethylase
por: Walport, Louise J., et al.
Publicado: (2014)

Demonstration of Phosphoryl Group Transfer Indicates That the ATP-binding Cassette (ABC) Transporter Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Exhibits Adenylate Kinase Activity
por: Randak, Christoph O., et al.
Publicado: (2012)

Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states
por: Dall, Elfriede, et al.
Publicado: (2018)

ATP and AMP Mutually Influence Their Interaction with the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) at Separate Binding Sites
por: Randak, Christoph O., et al.
Publicado: (2013)

The Progesterone 5β-Reductase/Iridoid Synthase Family: A Catalytic Reservoir for Specialized Metabolism across Land Plants
por: Nguyen, Trinh-Don, et al.
Publicado: (2020)

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor
por: Tarhonskaya, Hanna, et al.
Publicado: (2015)

Mechanism of Ferrous Iron Binding and Oxidation by Ferritin from a Pennate Diatom
por: Pfaffen, Stephanie, et al.
Publicado: (2013)

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression
por: Fisher, Nicholas, et al.
Publicado: (2012)

A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage
por: Pfaffen, Stephanie, et al.
Publicado: (2015)

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
por: Walsh, John G., et al.
Publicado: (2011)

Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling
por: Ukpabi, Georgia, et al.
Publicado: (2012)

Dissecting the Catalytic Mechanism of Trypanosoma brucei Trypanothione Synthetase by Kinetic Analysis and Computational Modeling
por: Leroux, Alejandro E., et al.
Publicado: (2013)

A Conformational Sampling Model for Radical Catalysis in Pyridoxal Phosphate- and Cobalamin-dependent Enzymes
por: Menon, Binuraj R. K., et al.
Publicado: (2014)

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
por: Singleton, Rachelle S., et al.
Publicado: (2011)

Mechanism of Thiosulfate Oxidation in the SoxA Family of Cysteine-ligated Cytochromes
por: Grabarczyk, Daniel B., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_729juapplb05jsn52or5ipq216