Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. mGluRs can form both constitutive ho...

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Detalles Bibliográficos
Autores principales: Liu, Junke, Zhang, Zongyong, Moreno-Delgado, David, Dalton, James AR, Rovira, Xavier, Trapero, Ana, Goudet, Cyril, Llebaria, Amadeu, Giraldo, Jesús, Yuan, Qilin, Rondard, Philippe, Huang, Siluo, Liu, Jianfeng, Pin, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582870/
https://www.ncbi.nlm.nih.gov/pubmed/28829739
http://dx.doi.org/10.7554/eLife.26985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582870/
https://www.ncbi.nlm.nih.gov/pubmed/28829739
http://dx.doi.org/10.7554/eLife.26985

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