Cargando…

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. mGluRs can form both constitutive ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Junke, Zhang, Zongyong, Moreno-Delgado, David, Dalton, James AR, Rovira, Xavier, Trapero, Ana, Goudet, Cyril, Llebaria, Amadeu, Giraldo, Jesús, Yuan, Qilin, Rondard, Philippe, Huang, Siluo, Liu, Jianfeng, Pin, Jean-Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582870/ https://www.ncbi.nlm.nih.gov/pubmed/28829739 http://dx.doi.org/10.7554/eLife.26985

Ejemplares similares

Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface
por: Liu, Lei, et al.
Publicado: (2021)

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective
por: Dalton, James A.R., et al.
Publicado: (2016)

Optical control of pain in vivo with a photoactive mGlu(5) receptor negative allosteric modulator
por: Font, Joan, et al.
Publicado: (2017)

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
por: Font, Joan, et al.
Publicado: (2018)

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells
por: Moreno Delgado, David, et al.
Publicado: (2017)

A Light-Controlled Allosteric Modulator Unveils a Role for mGlu(4) Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex
por: Bossi, Simon, et al.
Publicado: (2018)

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals
por: Gómez-Santacana, Xavier, et al.
Publicado: (2016)

Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand
por: Dalton, James A. R., et al.
Publicado: (2017)

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state
por: Cao, Anne-Marinette, et al.
Publicado: (2021)

Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
por: Nasrallah, Chady, et al.
Publicado: (2021)

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
por: Kojetin, Douglas J., et al.
Publicado: (2015)

A New Family of Receptor Tyrosine Kinases with a Venus Flytrap Binding Domain in Insects and Other Invertebrates Activated by Aminoacids
por: Ahier, Arnaud, et al.
Publicado: (2009)

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
por: Xue, Li, et al.
Publicado: (2019)

Complex GABA(B) receptor complexes: how to generate multiple functionally distinct units from a single receptor
por: Xu, Chanjuan, et al.
Publicado: (2014)

Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
por: Liu, Junke, et al.
Publicado: (2022)

Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
por: Ma, Tengfei, et al.
Publicado: (2017)

Challenges in the Discovery and Optimization of mGlu(2/4) Heterodimer Positive Allosteric Modulators
por: Fulton, Mark Gallant, et al.
Publicado: (2019)

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
por: Scholler, Pauline, et al.
Publicado: (2017)

Visible-Light-Controlled Histone Deacetylase Inhibitors for Targeted Cancer Therapy
por: Josa-Culleré, Laia, et al.
Publicado: (2023)

Direct coupling of detergent purified human mGlu(5) receptor to the heterotrimeric G proteins Gq and Gs
por: Nasrallah, Chady, et al.
Publicado: (2018)

Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction
por: Liang, Yuan, et al.
Publicado: (2023)

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin
por: Kahsai, Alem W., et al.
Publicado: (2023)

Concerted conformational changes control metabotropic glutamate receptor activity
por: Lecat-Guillet, Nathalie, et al.
Publicado: (2023)

Allosteric Modulators of GABA(B) Receptors: Mechanism of Action and Therapeutic Perspective
por: Pin, Jean-Philippe, et al.
Publicado: (2007)

Insights into adenosine A(2A) receptor activation through cooperative modulation of agonist and allosteric lipid interactions
por: Bruzzese, Agustín, et al.
Publicado: (2020)

The allosteric behavior of Fur mediates oxidative stress signal transduction in Helicobacter pylori
por: Pelliciari, Simone, et al.
Publicado: (2015)

Targeting the Brain with Single-Domain Antibodies: Greater Potential Than Stated So Far?
por: Tsitokana, Mireille Elodie, et al.
Publicado: (2023)

Equimolar heterodimers in microtubules
Publicado: (1982)

Heterodimers reign in the embryo
por: Tajer, Benjamin, et al.
Publicado: (2017)

PROK2/PROKR2 Signaling and Kallmann Syndrome
por: Dodé, Catherine, et al.
Publicado: (2013)

Correction: Photoswitchable dynasore analogs to control endocytosis with light
por: Camarero, Núria, et al.
Publicado: (2020)

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα
por: Fantauzzo, Katherine A., et al.
Publicado: (2016)

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ
por: Mensa, Bruk, et al.
Publicado: (2021)

Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions
por: Bruzzese, Agustín, et al.
Publicado: (2018)

A Photoswitchable Ligand Targeting the β(1)‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm
por: Duran‐Corbera, Anna, et al.
Publicado: (2022)

Allosteric modulation of integral protein activity by differential stress in asymmetric membranes
por: Piller, Paulina, et al.
Publicado: (2023)

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer
por: Parenty, Geraldine, et al.
Publicado: (2008)

Molecular and cellular factors control signal transduction via switchable allosteric modulator proteins (SAMPs)
por: Babel, Heiko, et al.
Publicado: (2016)

Ligand-Binding-Site Structure Shapes Allosteric Signal Transduction and the Evolution of Allostery in Protein Complexes
por: Abrusán, György, et al.
Publicado: (2019)

Control of Theta Oscillatory Activity Underlying Fear Expression by mGlu(5) Receptors
por: Matulewicz, Pawel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mq98vdsmunh2381r5leotbkl45