The development of an effective synthetic route of lesinurad (RDEA594)

BACKGROUND: Lesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic routes, such as expensive materials, environmental pollution and poor yield. RESUL...

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Detalles Bibliográficos
Autores principales: Meng, Qing, Zhao, Tong, Kang, Dongwei, Huang, Boshi, Zhan, Peng, Liu, Xinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583131/
https://www.ncbi.nlm.nih.gov/pubmed/29086884
http://dx.doi.org/10.1186/s13065-017-0316-y
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author Meng, Qing
Zhao, Tong
Kang, Dongwei
Huang, Boshi
Zhan, Peng
Liu, Xinyong
author_facet Meng, Qing
Zhao, Tong
Kang, Dongwei
Huang, Boshi
Zhan, Peng
Liu, Xinyong
author_sort Meng, Qing
collection PubMed
description BACKGROUND: Lesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic routes, such as expensive materials, environmental pollution and poor yield. RESULTS: In this study, an efficient, practical and environmentally-friendly synthetic route of lesinurad is reported. The main advantages of this route include inexpensive starting materials, mild conditions and acceptable overall yield (38.8%). CONCLUSION: Generally, this procedure is reasonable, reliable and suitable for industrial production. [Figure: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13065-017-0316-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-55831312017-09-22 The development of an effective synthetic route of lesinurad (RDEA594) Meng, Qing Zhao, Tong Kang, Dongwei Huang, Boshi Zhan, Peng Liu, Xinyong Chem Cent J Research Article BACKGROUND: Lesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic routes, such as expensive materials, environmental pollution and poor yield. RESULTS: In this study, an efficient, practical and environmentally-friendly synthetic route of lesinurad is reported. The main advantages of this route include inexpensive starting materials, mild conditions and acceptable overall yield (38.8%). CONCLUSION: Generally, this procedure is reasonable, reliable and suitable for industrial production. [Figure: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13065-017-0316-y) contains supplementary material, which is available to authorized users. Springer International Publishing 2017-09-05 /pmc/articles/PMC5583131/ /pubmed/29086884 http://dx.doi.org/10.1186/s13065-017-0316-y Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Meng, Qing
Zhao, Tong
Kang, Dongwei
Huang, Boshi
Zhan, Peng
Liu, Xinyong
The development of an effective synthetic route of lesinurad (RDEA594)
title The development of an effective synthetic route of lesinurad (RDEA594)
title_full The development of an effective synthetic route of lesinurad (RDEA594)
title_fullStr The development of an effective synthetic route of lesinurad (RDEA594)
title_full_unstemmed The development of an effective synthetic route of lesinurad (RDEA594)
title_short The development of an effective synthetic route of lesinurad (RDEA594)
title_sort development of an effective synthetic route of lesinurad (rdea594)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583131/
https://www.ncbi.nlm.nih.gov/pubmed/29086884
http://dx.doi.org/10.1186/s13065-017-0316-y
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