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Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we show that histone deacetylase Sirt6 protects against podocyte injury through epigenetic regulation of Notch si...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583183/ https://www.ncbi.nlm.nih.gov/pubmed/28871079 http://dx.doi.org/10.1038/s41467-017-00498-4 |