Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we show that histone deacetylase Sirt6 protects against podocyte injury through epigenetic regulation of Notch si...

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Detalles Bibliográficos
Autores principales: Liu, Min, Liang, Kaili, Zhen, Junhui, Zhou, Meng, Wang, Xiaojie, Wang, Ziying, Wei, Xinbing, Zhang, Yan, Sun, Yu, Zhou, Zhuanli, Su, Hua, Zhang, Chun, Li, Ningjun, Gao, Chengjiang, Peng, Jun, Yi, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583183/
https://www.ncbi.nlm.nih.gov/pubmed/28871079
http://dx.doi.org/10.1038/s41467-017-00498-4

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