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Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load
In humans and murine models of malaria, intradermal immunization (ID-I) with genetically attenuated sporozoites that arrest in liver induces lower protective immunity than intravenous immunization (IV-I). It is unclear whether this difference is caused by fewer sporozoites migrating into the liver o...
Autores principales: | Haeberlein, Simone, Chevalley-Maurel, Séverine, Ozir-Fazalalikhan, Arifa, Koppejan, Hester, Winkel, Beatrice M. F., Ramesar, Jai, Khan, Shahid M., Sauerwein, Robert W., Roestenberg, Meta, Janse, Chris J., Smits, Hermelijn H., Franke-Fayard, Blandine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583236/ https://www.ncbi.nlm.nih.gov/pubmed/28871201 http://dx.doi.org/10.1038/s41598-017-10480-1 |
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