Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1)

HSP47/SERPINH1 is key-regulator for collagen biosynthesis and its structural assembly. To date, there is no comprehensive study on the phylogenetic history of HSP47. Herein we illustrate the evolutionary history of HSP47/SERPINH1 along with sequence, structural and syntenic traits for HSP47/SERPINH1...

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Autores principales: Kumar, Abhishek, Bhandari, Anita, Sarde, Sandeep J., Goswami, Chandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583329/
https://www.ncbi.nlm.nih.gov/pubmed/28871169
http://dx.doi.org/10.1038/s41598-017-10740-0
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author Kumar, Abhishek
Bhandari, Anita
Sarde, Sandeep J.
Goswami, Chandan
author_facet Kumar, Abhishek
Bhandari, Anita
Sarde, Sandeep J.
Goswami, Chandan
author_sort Kumar, Abhishek
collection PubMed
description HSP47/SERPINH1 is key-regulator for collagen biosynthesis and its structural assembly. To date, there is no comprehensive study on the phylogenetic history of HSP47. Herein we illustrate the evolutionary history of HSP47/SERPINH1 along with sequence, structural and syntenic traits for HSP47/SERPINH1. We have identified ancestral HSP47/SERPINH1 locus in Japanese lamprey (Lethenteron japonicum). This gene remains on the same or similar locus for ~500 million years (MY), but chromosomal duplication was observed in ray-finned fishes, leading into three sets of three sets (I-III) of HSP47/SERPINH1. Two novel introns were inserted at the positions 36b and 102b in the first exon of only HSP47_1 gene from the selected ray-finned fishes. On the evolutionary time scale, the events of HSP47 duplications took placed between 416–360 MY ago (MYA) while intron insertion dates back to 231–190 MYA after early divergence of ray-finned fishes.
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spelling pubmed-55833292017-09-06 Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1) Kumar, Abhishek Bhandari, Anita Sarde, Sandeep J. Goswami, Chandan Sci Rep Article HSP47/SERPINH1 is key-regulator for collagen biosynthesis and its structural assembly. To date, there is no comprehensive study on the phylogenetic history of HSP47. Herein we illustrate the evolutionary history of HSP47/SERPINH1 along with sequence, structural and syntenic traits for HSP47/SERPINH1. We have identified ancestral HSP47/SERPINH1 locus in Japanese lamprey (Lethenteron japonicum). This gene remains on the same or similar locus for ~500 million years (MY), but chromosomal duplication was observed in ray-finned fishes, leading into three sets of three sets (I-III) of HSP47/SERPINH1. Two novel introns were inserted at the positions 36b and 102b in the first exon of only HSP47_1 gene from the selected ray-finned fishes. On the evolutionary time scale, the events of HSP47 duplications took placed between 416–360 MY ago (MYA) while intron insertion dates back to 231–190 MYA after early divergence of ray-finned fishes. Nature Publishing Group UK 2017-09-04 /pmc/articles/PMC5583329/ /pubmed/28871169 http://dx.doi.org/10.1038/s41598-017-10740-0 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kumar, Abhishek
Bhandari, Anita
Sarde, Sandeep J.
Goswami, Chandan
Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1)
title Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1)
title_full Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1)
title_fullStr Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1)
title_full_unstemmed Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1)
title_short Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1)
title_sort ancestry & molecular evolutionary analyses of heat shock protein 47 kda (hsp47/serpinh1)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583329/
https://www.ncbi.nlm.nih.gov/pubmed/28871169
http://dx.doi.org/10.1038/s41598-017-10740-0
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