Epigenetic analysis confirms no accelerated brain aging in schizophrenia

Epigenetic aging is associated with several biological mechanisms and diseases. We assessed two brain data sets, one small (n = 48) and one large (n = 392), to test epigenetic aging in schizophrenia. DNA methylation age from frontal cortex was significantly correlated with chronological age but no s...

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Detalles Bibliográficos
Autores principales: Voisey, Joanne, Lawford, Bruce R., Morris, C. Phillip, Wockner, Leesa F., Noble, Ernest P., Young, Ross McD, Mehta, Divya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583345/
https://www.ncbi.nlm.nih.gov/pubmed/28871179
http://dx.doi.org/10.1038/s41537-017-0026-4
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author Voisey, Joanne
Lawford, Bruce R.
Morris, C. Phillip
Wockner, Leesa F.
Noble, Ernest P.
Young, Ross McD
Mehta, Divya
author_facet Voisey, Joanne
Lawford, Bruce R.
Morris, C. Phillip
Wockner, Leesa F.
Noble, Ernest P.
Young, Ross McD
Mehta, Divya
author_sort Voisey, Joanne
collection PubMed
description Epigenetic aging is associated with several biological mechanisms and diseases. We assessed two brain data sets, one small (n = 48) and one large (n = 392), to test epigenetic aging in schizophrenia. DNA methylation age from frontal cortex was significantly correlated with chronological age but no significant differences in DNA methylation age acceleration between schizophrenia cases and controls were observed in both data sets. Our results were consistent with a previous study investigating schizophrenia and epigenetic aging in superior temporal gyrus. Future studies targeting different brain regions and defined cell types are warranted to further investigate accelerated brain aging in schizophrenia.
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spelling pubmed-55833452017-09-07 Epigenetic analysis confirms no accelerated brain aging in schizophrenia Voisey, Joanne Lawford, Bruce R. Morris, C. Phillip Wockner, Leesa F. Noble, Ernest P. Young, Ross McD Mehta, Divya NPJ Schizophr Brief Communication Epigenetic aging is associated with several biological mechanisms and diseases. We assessed two brain data sets, one small (n = 48) and one large (n = 392), to test epigenetic aging in schizophrenia. DNA methylation age from frontal cortex was significantly correlated with chronological age but no significant differences in DNA methylation age acceleration between schizophrenia cases and controls were observed in both data sets. Our results were consistent with a previous study investigating schizophrenia and epigenetic aging in superior temporal gyrus. Future studies targeting different brain regions and defined cell types are warranted to further investigate accelerated brain aging in schizophrenia. Nature Publishing Group UK 2017-09-04 /pmc/articles/PMC5583345/ /pubmed/28871179 http://dx.doi.org/10.1038/s41537-017-0026-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Voisey, Joanne
Lawford, Bruce R.
Morris, C. Phillip
Wockner, Leesa F.
Noble, Ernest P.
Young, Ross McD
Mehta, Divya
Epigenetic analysis confirms no accelerated brain aging in schizophrenia
title Epigenetic analysis confirms no accelerated brain aging in schizophrenia
title_full Epigenetic analysis confirms no accelerated brain aging in schizophrenia
title_fullStr Epigenetic analysis confirms no accelerated brain aging in schizophrenia
title_full_unstemmed Epigenetic analysis confirms no accelerated brain aging in schizophrenia
title_short Epigenetic analysis confirms no accelerated brain aging in schizophrenia
title_sort epigenetic analysis confirms no accelerated brain aging in schizophrenia
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583345/
https://www.ncbi.nlm.nih.gov/pubmed/28871179
http://dx.doi.org/10.1038/s41537-017-0026-4
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