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High-fat diet increases pain behaviors in rats with or without obesity

Obesity is associated with increased risk for chronic pain. Basic mechanisms for this association are poorly understood. Using a milder version of a radicular pain model, local inflammation of the dorsal root ganglion (DRG), we observed marked increases in mechanical and cold allodynia in rats of bo...

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Autores principales: Song, Zongbin, Xie, Wenrui, Chen, Sisi, Strong, Judith A., Print, Mason S., Wang, Joy I., Shareef, Aleeya F., Ulrich-Lai, Yvonne M., Zhang, Jun-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583349/
https://www.ncbi.nlm.nih.gov/pubmed/28871134
http://dx.doi.org/10.1038/s41598-017-10458-z
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author Song, Zongbin
Xie, Wenrui
Chen, Sisi
Strong, Judith A.
Print, Mason S.
Wang, Joy I.
Shareef, Aleeya F.
Ulrich-Lai, Yvonne M.
Zhang, Jun-Ming
author_facet Song, Zongbin
Xie, Wenrui
Chen, Sisi
Strong, Judith A.
Print, Mason S.
Wang, Joy I.
Shareef, Aleeya F.
Ulrich-Lai, Yvonne M.
Zhang, Jun-Ming
author_sort Song, Zongbin
collection PubMed
description Obesity is associated with increased risk for chronic pain. Basic mechanisms for this association are poorly understood. Using a milder version of a radicular pain model, local inflammation of the dorsal root ganglion (DRG), we observed marked increases in mechanical and cold allodynia in rats of both sexes that were maintained on a high-fat diet (HFD) for 6 weeks prior to DRG inflammation. Notably, this increase in pain-related behaviors occurred in both Long-Evans and Sprague-Dawley rats despite the fact that the 6-week HFD exposure induced obesity (e.g., increased insulin, leptin, weight, and percent body fat) in the Long-Evans, but not Sprague-Dawley, strains. This suggested that HFD, rather than obesity per se, increased pain behaviors. Increased pain behaviors were observed even after a much shorter (1 week) exposure to the HFD but the effect was smaller. HFD also increased behavioral responses and paw swelling to paw injection of complete Freund’s adjuvant, a model of peripheral inflammatory pain. No change was detected in plasma cytokine levels in HFD rats. However, increased macrophage infiltration of the DRG was observed in response to the HFD, absent any pain model. The results suggest that HFD can increase pain even when it does not cause obesity.
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spelling pubmed-55833492017-09-06 High-fat diet increases pain behaviors in rats with or without obesity Song, Zongbin Xie, Wenrui Chen, Sisi Strong, Judith A. Print, Mason S. Wang, Joy I. Shareef, Aleeya F. Ulrich-Lai, Yvonne M. Zhang, Jun-Ming Sci Rep Article Obesity is associated with increased risk for chronic pain. Basic mechanisms for this association are poorly understood. Using a milder version of a radicular pain model, local inflammation of the dorsal root ganglion (DRG), we observed marked increases in mechanical and cold allodynia in rats of both sexes that were maintained on a high-fat diet (HFD) for 6 weeks prior to DRG inflammation. Notably, this increase in pain-related behaviors occurred in both Long-Evans and Sprague-Dawley rats despite the fact that the 6-week HFD exposure induced obesity (e.g., increased insulin, leptin, weight, and percent body fat) in the Long-Evans, but not Sprague-Dawley, strains. This suggested that HFD, rather than obesity per se, increased pain behaviors. Increased pain behaviors were observed even after a much shorter (1 week) exposure to the HFD but the effect was smaller. HFD also increased behavioral responses and paw swelling to paw injection of complete Freund’s adjuvant, a model of peripheral inflammatory pain. No change was detected in plasma cytokine levels in HFD rats. However, increased macrophage infiltration of the DRG was observed in response to the HFD, absent any pain model. The results suggest that HFD can increase pain even when it does not cause obesity. Nature Publishing Group UK 2017-09-04 /pmc/articles/PMC5583349/ /pubmed/28871134 http://dx.doi.org/10.1038/s41598-017-10458-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Song, Zongbin
Xie, Wenrui
Chen, Sisi
Strong, Judith A.
Print, Mason S.
Wang, Joy I.
Shareef, Aleeya F.
Ulrich-Lai, Yvonne M.
Zhang, Jun-Ming
High-fat diet increases pain behaviors in rats with or without obesity
title High-fat diet increases pain behaviors in rats with or without obesity
title_full High-fat diet increases pain behaviors in rats with or without obesity
title_fullStr High-fat diet increases pain behaviors in rats with or without obesity
title_full_unstemmed High-fat diet increases pain behaviors in rats with or without obesity
title_short High-fat diet increases pain behaviors in rats with or without obesity
title_sort high-fat diet increases pain behaviors in rats with or without obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583349/
https://www.ncbi.nlm.nih.gov/pubmed/28871134
http://dx.doi.org/10.1038/s41598-017-10458-z
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