Identification of HSP90 inhibitors as a novel class of senolytics

Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased senescent cell burden in various tissues is a major contributor to aging and age-related diseases. Recently, a new class of drugs termed senolytics were demonstrated to extending healthspan, reducing frailty a...

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Detalles Bibliográficos
Autores principales: Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583353/
https://www.ncbi.nlm.nih.gov/pubmed/28871086
http://dx.doi.org/10.1038/s41467-017-00314-z

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