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Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review

Few reports have presented data and results on functional (i.e., nuclear medicine) imaging of paragangliomas and pheochromocytomas (PGLs/PHEOs) for von Hippel–Lindau (VHL) patients. Nuclear medicine localization modalities for chromaffin tumors can be specific or nonspecific. Specific methods make u...

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Autores principales: Ilias, Ioannis, Meristoudis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Codon Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583378/
https://www.ncbi.nlm.nih.gov/pubmed/28890865
http://dx.doi.org/10.15586/jkcvhl.2017.92
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author Ilias, Ioannis
Meristoudis, Georgios
author_facet Ilias, Ioannis
Meristoudis, Georgios
author_sort Ilias, Ioannis
collection PubMed
description Few reports have presented data and results on functional (i.e., nuclear medicine) imaging of paragangliomas and pheochromocytomas (PGLs/PHEOs) for von Hippel–Lindau (VHL) patients. Nuclear medicine localization modalities for chromaffin tumors can be specific or nonspecific. Specific methods make use of the expression of the human norepinephrine transporter (hNET) and vesicular monoamine transporters (VMATs) by these tumors. These permit the use of radiolabeled ligands that enter the synthesis and storage pathway of catecholamines. Nonspecific methods are not related to the synthesis, uptake, or storage of catecholamines but make use of the tumors’ high glucose metabolism or expression of somatostatin receptors. Consensuses and guidelines suggest that metastatic and sporadic PHEOs/PGLs in VHL patients (as in patients with chromaffin tumors of yet unknown genotype) should be evaluated first with (18)F-dihydroxyphenylalanine ((18)F-DOPA) positron emission tomography/computed tomography (PET/CT). The functional imaging of second choice is (123)I-metaiodobenzylguanidine ((123)I-MIBG) for PHEOs in VHL patients. (123)I-MIBG, (68)Ga-DOTATATE/DOTATOC/DOTANOC PET/CT, or (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT can be a second choice of functional imaging for PGLs in VHL patients.
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spelling pubmed-55833782017-09-08 Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review Ilias, Ioannis Meristoudis, Georgios J Kidney Cancer VHL Review Article Few reports have presented data and results on functional (i.e., nuclear medicine) imaging of paragangliomas and pheochromocytomas (PGLs/PHEOs) for von Hippel–Lindau (VHL) patients. Nuclear medicine localization modalities for chromaffin tumors can be specific or nonspecific. Specific methods make use of the expression of the human norepinephrine transporter (hNET) and vesicular monoamine transporters (VMATs) by these tumors. These permit the use of radiolabeled ligands that enter the synthesis and storage pathway of catecholamines. Nonspecific methods are not related to the synthesis, uptake, or storage of catecholamines but make use of the tumors’ high glucose metabolism or expression of somatostatin receptors. Consensuses and guidelines suggest that metastatic and sporadic PHEOs/PGLs in VHL patients (as in patients with chromaffin tumors of yet unknown genotype) should be evaluated first with (18)F-dihydroxyphenylalanine ((18)F-DOPA) positron emission tomography/computed tomography (PET/CT). The functional imaging of second choice is (123)I-metaiodobenzylguanidine ((123)I-MIBG) for PHEOs in VHL patients. (123)I-MIBG, (68)Ga-DOTATATE/DOTATOC/DOTANOC PET/CT, or (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT can be a second choice of functional imaging for PGLs in VHL patients. Codon Publications 2017-09-04 /pmc/articles/PMC5583378/ /pubmed/28890865 http://dx.doi.org/10.15586/jkcvhl.2017.92 Text en © Ilias I and Meristoudis G http://creativecommons.org/licenses/by/4.0 This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0).
spellingShingle Review Article
Ilias, Ioannis
Meristoudis, Georgios
Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review
title Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review
title_full Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review
title_fullStr Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review
title_full_unstemmed Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review
title_short Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review
title_sort functional imaging of paragangliomas with an emphasis on von hippel–lindau-associated disease: a mini review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583378/
https://www.ncbi.nlm.nih.gov/pubmed/28890865
http://dx.doi.org/10.15586/jkcvhl.2017.92
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