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Fatty Acid Concentration and Phase Transitions Modulate Aβ Aggregation Pathways

Aggregation of amyloid β (Aβ) peptides is a significant event that underpins Alzheimer disease (AD) pathology. Aβ aggregates, especially the low-molecular weight oligomers, are the primary toxic agents in AD and hence, there is increasing interest in understanding their formation and behavior. Aggre...

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Detalles Bibliográficos
Autores principales: Rana, Pratip, Dean, Dexter N., Steen, Edward D., Vaidya, Ashwin, Rangachari, Vijayaraghavan, Ghosh, Preetam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583381/
https://www.ncbi.nlm.nih.gov/pubmed/28871093
http://dx.doi.org/10.1038/s41598-017-09794-x