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Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV
Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate i...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Authors.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583508/ https://www.ncbi.nlm.nih.gov/pubmed/28854372 http://dx.doi.org/10.1016/j.celrep.2017.08.023 |
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| author | Rechtien, Anne Richert, Laura Lorenzo, Hadrien Martrus, Gloria Hejblum, Boris Dahlke, Christine Kasonta, Rahel Zinser, Madeleine Stubbe, Hans Matschl, Urte Lohse, Ansgar Krähling, Verena Eickmann, Markus Becker, Stephan Thiébaut, Rodolphe Altfeld, Marcus Addo, Marylyn |
| author_facet | Rechtien, Anne Richert, Laura Lorenzo, Hadrien Martrus, Gloria Hejblum, Boris Dahlke, Christine Kasonta, Rahel Zinser, Madeleine Stubbe, Hans Matschl, Urte Lohse, Ansgar Krähling, Verena Eickmann, Markus Becker, Stephan Thiébaut, Rodolphe Altfeld, Marcus Addo, Marylyn |
| author_sort | Rechtien, Anne |
| collection | PubMed |
| description | Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10. |
| format | Online Article Text |
| id | pubmed-5583508 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | The Authors. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55835082017-09-14 Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV Rechtien, Anne Richert, Laura Lorenzo, Hadrien Martrus, Gloria Hejblum, Boris Dahlke, Christine Kasonta, Rahel Zinser, Madeleine Stubbe, Hans Matschl, Urte Lohse, Ansgar Krähling, Verena Eickmann, Markus Becker, Stephan Thiébaut, Rodolphe Altfeld, Marcus Addo, Marylyn Cell Rep Article Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10. The Authors. 2017-08-29 2017-08-29 /pmc/articles/PMC5583508/ /pubmed/28854372 http://dx.doi.org/10.1016/j.celrep.2017.08.023 Text en © 2017 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Rechtien, Anne Richert, Laura Lorenzo, Hadrien Martrus, Gloria Hejblum, Boris Dahlke, Christine Kasonta, Rahel Zinser, Madeleine Stubbe, Hans Matschl, Urte Lohse, Ansgar Krähling, Verena Eickmann, Markus Becker, Stephan Thiébaut, Rodolphe Altfeld, Marcus Addo, Marylyn Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV |
| title | Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV |
| title_full | Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV |
| title_fullStr | Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV |
| title_full_unstemmed | Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV |
| title_short | Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV |
| title_sort | systems vaccinology identifies an early innate immune signature as a correlate of antibody responses to the ebola vaccine rvsv-zebov |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583508/ https://www.ncbi.nlm.nih.gov/pubmed/28854372 http://dx.doi.org/10.1016/j.celrep.2017.08.023 |
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