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Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance
Epithelial-mesenchymal transition (EMT) has been linked with aggressive tumor biology and therapy resistance. It plays central role not only in the generation of cancer stem cells (CSCs) but also direct them across the multiple organ systems to promote tumor recurrence and metastasis. CSCs are repor...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583530/ https://www.ncbi.nlm.nih.gov/pubmed/28928908 http://dx.doi.org/10.4252/wjsc.v9.i8.118 |
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author | Garg, Minal |
author_facet | Garg, Minal |
author_sort | Garg, Minal |
collection | PubMed |
description | Epithelial-mesenchymal transition (EMT) has been linked with aggressive tumor biology and therapy resistance. It plays central role not only in the generation of cancer stem cells (CSCs) but also direct them across the multiple organ systems to promote tumor recurrence and metastasis. CSCs are reported to express stem cell genes as well as specific cell surface markers and allow aberrant differentiation of progenies. It facilitates cancer cells to leave primary tumor, acquire migratory characteristics, grow into new environment and develop radio-chemo-resistance. Based on the current information, present review discusses and summarizes the recent advancements on the molecular mechanisms that derive epithelial plasticity and its major role in generating a subset of tumor cells with stemness properties and pathophysiological spread of tumor. This paper further highlights the critical need to examine the regulation of EMT and CSC pathways in identifying the novel probable therapeutic targets. These improved therapeutic strategies based on the co-administration of inhibitors of EMT, CSCs as well as differentiated tumor cells may provide improved anti-neoplastic response with no tumor relapse. |
format | Online Article Text |
id | pubmed-5583530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-55835302017-09-19 Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance Garg, Minal World J Stem Cells Minireviews Epithelial-mesenchymal transition (EMT) has been linked with aggressive tumor biology and therapy resistance. It plays central role not only in the generation of cancer stem cells (CSCs) but also direct them across the multiple organ systems to promote tumor recurrence and metastasis. CSCs are reported to express stem cell genes as well as specific cell surface markers and allow aberrant differentiation of progenies. It facilitates cancer cells to leave primary tumor, acquire migratory characteristics, grow into new environment and develop radio-chemo-resistance. Based on the current information, present review discusses and summarizes the recent advancements on the molecular mechanisms that derive epithelial plasticity and its major role in generating a subset of tumor cells with stemness properties and pathophysiological spread of tumor. This paper further highlights the critical need to examine the regulation of EMT and CSC pathways in identifying the novel probable therapeutic targets. These improved therapeutic strategies based on the co-administration of inhibitors of EMT, CSCs as well as differentiated tumor cells may provide improved anti-neoplastic response with no tumor relapse. Baishideng Publishing Group Inc 2017-08-26 2017-08-26 /pmc/articles/PMC5583530/ /pubmed/28928908 http://dx.doi.org/10.4252/wjsc.v9.i8.118 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Minireviews Garg, Minal Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance |
title | Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance |
title_full | Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance |
title_fullStr | Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance |
title_full_unstemmed | Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance |
title_short | Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance |
title_sort | epithelial plasticity and cancer stem cells: major mechanisms of cancer pathogenesis and therapy resistance |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583530/ https://www.ncbi.nlm.nih.gov/pubmed/28928908 http://dx.doi.org/10.4252/wjsc.v9.i8.118 |
work_keys_str_mv | AT gargminal epithelialplasticityandcancerstemcellsmajormechanismsofcancerpathogenesisandtherapyresistance |