First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease

A neonate born to an Ebola virus–positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen...

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Autores principales: Dörnemann, Jenny, Burzio, Chiara, Ronsse, Axelle, Sprecher, Armand, De Clerck, Hilde, Van Herp, Michel, Kolié, Marie-Claire, Yosifiva, Vesselina, Caluwaerts, Severine, McElroy, Anita K., Antierens, Annick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583641/
https://www.ncbi.nlm.nih.gov/pubmed/28073857
http://dx.doi.org/10.1093/infdis/jiw493
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author Dörnemann, Jenny
Burzio, Chiara
Ronsse, Axelle
Sprecher, Armand
De Clerck, Hilde
Van Herp, Michel
Kolié, Marie-Claire
Yosifiva, Vesselina
Caluwaerts, Severine
McElroy, Anita K.
Antierens, Annick
author_facet Dörnemann, Jenny
Burzio, Chiara
Ronsse, Axelle
Sprecher, Armand
De Clerck, Hilde
Van Herp, Michel
Kolié, Marie-Claire
Yosifiva, Vesselina
Caluwaerts, Severine
McElroy, Anita K.
Antierens, Annick
author_sort Dörnemann, Jenny
collection PubMed
description A neonate born to an Ebola virus–positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.
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spelling pubmed-55836412018-01-15 First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease Dörnemann, Jenny Burzio, Chiara Ronsse, Axelle Sprecher, Armand De Clerck, Hilde Van Herp, Michel Kolié, Marie-Claire Yosifiva, Vesselina Caluwaerts, Severine McElroy, Anita K. Antierens, Annick J Infect Dis Major Articles and Brief Reports A neonate born to an Ebola virus–positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus. Oxford University Press 2017-01-15 2017-01-23 /pmc/articles/PMC5583641/ /pubmed/28073857 http://dx.doi.org/10.1093/infdis/jiw493 Text en © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Dörnemann, Jenny
Burzio, Chiara
Ronsse, Axelle
Sprecher, Armand
De Clerck, Hilde
Van Herp, Michel
Kolié, Marie-Claire
Yosifiva, Vesselina
Caluwaerts, Severine
McElroy, Anita K.
Antierens, Annick
First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease
title First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease
title_full First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease
title_fullStr First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease
title_full_unstemmed First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease
title_short First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease
title_sort first newborn baby to receive experimental therapies survives ebola virus disease
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583641/
https://www.ncbi.nlm.nih.gov/pubmed/28073857
http://dx.doi.org/10.1093/infdis/jiw493
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