Cargando…

The transformation of the nuclear nanoarchitecture in human field carcinogenesis

Morphological alterations of the nuclear texture are a hallmark of carcinogenesis. At later stages of disease, these changes are well characterized and detectable by light microscopy. Evidence suggests that similar albeit nanoscopic alterations develop at the predysplastic stages of carcinogenesis....

Descripción completa

Detalles Bibliográficos
Autores principales: Bauer, Greta M, Stypula-Cyrus, Yolanda, Subramanian, Hariharan, Cherkezyan, Lusik, Viswanathan, Parvathi, Zhang, Di, Iyengar, Radha, Bagalkar, Saurabh, Derbas, Justin, Graff, Taylor, Gladstein, Scott, Almassalha, Luay M, Chandler, John E, Roy, Hemant K, Backman, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583697/
https://www.ncbi.nlm.nih.gov/pubmed/28884003
http://dx.doi.org/10.4155/fsoa-2017-0027
_version_ 1783261366661939200
author Bauer, Greta M
Stypula-Cyrus, Yolanda
Subramanian, Hariharan
Cherkezyan, Lusik
Viswanathan, Parvathi
Zhang, Di
Iyengar, Radha
Bagalkar, Saurabh
Derbas, Justin
Graff, Taylor
Gladstein, Scott
Almassalha, Luay M
Chandler, John E
Roy, Hemant K
Backman, Vadim
author_facet Bauer, Greta M
Stypula-Cyrus, Yolanda
Subramanian, Hariharan
Cherkezyan, Lusik
Viswanathan, Parvathi
Zhang, Di
Iyengar, Radha
Bagalkar, Saurabh
Derbas, Justin
Graff, Taylor
Gladstein, Scott
Almassalha, Luay M
Chandler, John E
Roy, Hemant K
Backman, Vadim
author_sort Bauer, Greta M
collection PubMed
description Morphological alterations of the nuclear texture are a hallmark of carcinogenesis. At later stages of disease, these changes are well characterized and detectable by light microscopy. Evidence suggests that similar albeit nanoscopic alterations develop at the predysplastic stages of carcinogenesis. Using the novel optical technique partial wave spectroscopic microscopy, we identified profound changes in the nanoscale chromatin topology in microscopically normal tissue as a common event in the field carcinogenesis of many cancers. In particular, higher-order chromatin structure at supranucleosomal length scales (20–200 nm) becomes exceedingly heterogeneous, a measure we quantify using the disorder strength (L(d)) of the spatial arrangement of chromatin density. Here, we review partial wave spectroscopic nanocytology clinical studies and the technology's promise as an early cancer screening technology.
format Online
Article
Text
id pubmed-5583697
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Future Science Ltd
record_format MEDLINE/PubMed
spelling pubmed-55836972017-09-07 The transformation of the nuclear nanoarchitecture in human field carcinogenesis Bauer, Greta M Stypula-Cyrus, Yolanda Subramanian, Hariharan Cherkezyan, Lusik Viswanathan, Parvathi Zhang, Di Iyengar, Radha Bagalkar, Saurabh Derbas, Justin Graff, Taylor Gladstein, Scott Almassalha, Luay M Chandler, John E Roy, Hemant K Backman, Vadim Future Sci OA Review Morphological alterations of the nuclear texture are a hallmark of carcinogenesis. At later stages of disease, these changes are well characterized and detectable by light microscopy. Evidence suggests that similar albeit nanoscopic alterations develop at the predysplastic stages of carcinogenesis. Using the novel optical technique partial wave spectroscopic microscopy, we identified profound changes in the nanoscale chromatin topology in microscopically normal tissue as a common event in the field carcinogenesis of many cancers. In particular, higher-order chromatin structure at supranucleosomal length scales (20–200 nm) becomes exceedingly heterogeneous, a measure we quantify using the disorder strength (L(d)) of the spatial arrangement of chromatin density. Here, we review partial wave spectroscopic nanocytology clinical studies and the technology's promise as an early cancer screening technology. Future Science Ltd 2017-05-05 /pmc/articles/PMC5583697/ /pubmed/28884003 http://dx.doi.org/10.4155/fsoa-2017-0027 Text en © Vadim Backman This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Bauer, Greta M
Stypula-Cyrus, Yolanda
Subramanian, Hariharan
Cherkezyan, Lusik
Viswanathan, Parvathi
Zhang, Di
Iyengar, Radha
Bagalkar, Saurabh
Derbas, Justin
Graff, Taylor
Gladstein, Scott
Almassalha, Luay M
Chandler, John E
Roy, Hemant K
Backman, Vadim
The transformation of the nuclear nanoarchitecture in human field carcinogenesis
title The transformation of the nuclear nanoarchitecture in human field carcinogenesis
title_full The transformation of the nuclear nanoarchitecture in human field carcinogenesis
title_fullStr The transformation of the nuclear nanoarchitecture in human field carcinogenesis
title_full_unstemmed The transformation of the nuclear nanoarchitecture in human field carcinogenesis
title_short The transformation of the nuclear nanoarchitecture in human field carcinogenesis
title_sort transformation of the nuclear nanoarchitecture in human field carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583697/
https://www.ncbi.nlm.nih.gov/pubmed/28884003
http://dx.doi.org/10.4155/fsoa-2017-0027
work_keys_str_mv AT bauergretam thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT stypulacyrusyolanda thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT subramanianhariharan thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT cherkezyanlusik thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT viswanathanparvathi thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT zhangdi thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT iyengarradha thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT bagalkarsaurabh thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT derbasjustin thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT grafftaylor thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT gladsteinscott thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT almassalhaluaym thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT chandlerjohne thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT royhemantk thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT backmanvadim thetransformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT bauergretam transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT stypulacyrusyolanda transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT subramanianhariharan transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT cherkezyanlusik transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT viswanathanparvathi transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT zhangdi transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT iyengarradha transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT bagalkarsaurabh transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT derbasjustin transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT grafftaylor transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT gladsteinscott transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT almassalhaluaym transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT chandlerjohne transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT royhemantk transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis
AT backmanvadim transformationofthenuclearnanoarchitectureinhumanfieldcarcinogenesis