Cargando…

Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage

AIM: Early breast cancer detection is important for intervention and prognosis. Advances in treatment and outcome require diagnostic tools with highly positive predictive value. PURPOSE: To study the potential role of quantitative MRI (qMRI) using T1/T2 ratios to differentiate benign from malignant...

Descripción completa

Detalles Bibliográficos
Autores principales: Malikova, Marina A, Tkacz, Jaroslaw N, Slanetz, Priscilla J, Guo, Chao-Yu, Aakil, Adam, Jara, Hernan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583698/
https://www.ncbi.nlm.nih.gov/pubmed/28883997
http://dx.doi.org/10.4155/fsoa-2016-0063
_version_ 1783261366890528768
author Malikova, Marina A
Tkacz, Jaroslaw N
Slanetz, Priscilla J
Guo, Chao-Yu
Aakil, Adam
Jara, Hernan
author_facet Malikova, Marina A
Tkacz, Jaroslaw N
Slanetz, Priscilla J
Guo, Chao-Yu
Aakil, Adam
Jara, Hernan
author_sort Malikova, Marina A
collection PubMed
description AIM: Early breast cancer detection is important for intervention and prognosis. Advances in treatment and outcome require diagnostic tools with highly positive predictive value. PURPOSE: To study the potential role of quantitative MRI (qMRI) using T1/T2 ratios to differentiate benign from malignant breast lesions. METHODS: A cross-sectional study of 69 women with 69 known or suspicious breast lesions were scanned with mixed-turbo spin echo pulse sequence. Patients were grouped according to histopathological assessment of disease stage: untreated malignant tumor, treated malignancy and benign disease. RESULTS & DISCUSSION: Elevated T1/T2 means were observed for biopsy-proven malignant lesions and for malignant lesions treated prior to qMRI with chemotherapy and/or radiation, as compared with benign lesions. The qMRI-obtained T1/T2 ratios correlated with histopathology. Analysis revealed correlation between elevated T1/T2 ratio and disease stage. This could provide valuable complementary information on tissue properties as an additional diagnostic tool.
format Online
Article
Text
id pubmed-5583698
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Future Science Ltd
record_format MEDLINE/PubMed
spelling pubmed-55836982017-09-07 Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage Malikova, Marina A Tkacz, Jaroslaw N Slanetz, Priscilla J Guo, Chao-Yu Aakil, Adam Jara, Hernan Future Sci OA Preliminary Communication AIM: Early breast cancer detection is important for intervention and prognosis. Advances in treatment and outcome require diagnostic tools with highly positive predictive value. PURPOSE: To study the potential role of quantitative MRI (qMRI) using T1/T2 ratios to differentiate benign from malignant breast lesions. METHODS: A cross-sectional study of 69 women with 69 known or suspicious breast lesions were scanned with mixed-turbo spin echo pulse sequence. Patients were grouped according to histopathological assessment of disease stage: untreated malignant tumor, treated malignancy and benign disease. RESULTS & DISCUSSION: Elevated T1/T2 means were observed for biopsy-proven malignant lesions and for malignant lesions treated prior to qMRI with chemotherapy and/or radiation, as compared with benign lesions. The qMRI-obtained T1/T2 ratios correlated with histopathology. Analysis revealed correlation between elevated T1/T2 ratio and disease stage. This could provide valuable complementary information on tissue properties as an additional diagnostic tool. Future Science Ltd 2017-05-02 /pmc/articles/PMC5583698/ /pubmed/28883997 http://dx.doi.org/10.4155/fsoa-2016-0063 Text en © Marina Malikova This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Preliminary Communication
Malikova, Marina A
Tkacz, Jaroslaw N
Slanetz, Priscilla J
Guo, Chao-Yu
Aakil, Adam
Jara, Hernan
Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage
title Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage
title_full Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage
title_fullStr Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage
title_full_unstemmed Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage
title_short Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage
title_sort evaluation of t1/t2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583698/
https://www.ncbi.nlm.nih.gov/pubmed/28883997
http://dx.doi.org/10.4155/fsoa-2016-0063
work_keys_str_mv AT malikovamarinaa evaluationoft1t2ratiosinapilotstudyasapotentialbiomarkerofbiopsyprovenbenignandmalignantbreastlesionsincorrelationwithhistopathologicaldiseasestage
AT tkaczjaroslawn evaluationoft1t2ratiosinapilotstudyasapotentialbiomarkerofbiopsyprovenbenignandmalignantbreastlesionsincorrelationwithhistopathologicaldiseasestage
AT slanetzpriscillaj evaluationoft1t2ratiosinapilotstudyasapotentialbiomarkerofbiopsyprovenbenignandmalignantbreastlesionsincorrelationwithhistopathologicaldiseasestage
AT guochaoyu evaluationoft1t2ratiosinapilotstudyasapotentialbiomarkerofbiopsyprovenbenignandmalignantbreastlesionsincorrelationwithhistopathologicaldiseasestage
AT aakiladam evaluationoft1t2ratiosinapilotstudyasapotentialbiomarkerofbiopsyprovenbenignandmalignantbreastlesionsincorrelationwithhistopathologicaldiseasestage
AT jarahernan evaluationoft1t2ratiosinapilotstudyasapotentialbiomarkerofbiopsyprovenbenignandmalignantbreastlesionsincorrelationwithhistopathologicaldiseasestage