Cargando…

Global Metabolomics Reveals the Metabolic Dysfunction in Ox-LDL Induced Macrophage-Derived Foam Cells

Atherosclerosis (AS) is a chronic disorder of large arteries that is a major risk factors of high morbidity and mortality. Oxidative modification LDL is one of the important contributors to atherogenesis. Macrophages take up ox-LDL and convert into foam cells, which is the hallmark of AS. To advance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Wenjuan, Wei, Ziyi, Dong, Jiaojiao, Duan, Feipeng, Chen, Kuikui, Chen, Chang, Liu, Jie, Yang, Xiaowei, Chen, Lianming, Xiao, Hongbin, Liu, An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583968/ https://www.ncbi.nlm.nih.gov/pubmed/28912717 http://dx.doi.org/10.3389/fphar.2017.00586

Ejemplares similares

Effects of frog skin peptide temporin-1CEa and its analogs on ox-LDL induced macrophage-derived foam cells
por: Yang, Xue-Feng, et al.
Publicado: (2023)

Protective effects of mitochondrial fission inhibition on ox-LDL induced VSMC foaming via metabolic reprogramming
por: Fang, Yijin, et al.
Publicado: (2022)

Traditional Chinese Medication Tongxinluo Attenuates Lipidosis in Ox-LDL-Stimulated Macrophages by Enhancing Beclin-1-Induced Autophagy
por: Chen, Yifei, et al.
Publicado: (2021)

Identifying the molecular targets of Salvia miltiorrhiza (SM) in ox-LDL induced macrophage-derived foam cells based on the integration of metabolomics and network pharmacology
por: Xu, W. J., et al.
Publicado: (2018)

Niacin Reverses Migratory Macrophage Foam Cell Arrest Mediated by oxLDL In Vitro
por: Huang, Hua, et al.
Publicado: (2014)

Quercetin Inhibits LPS-Induced Inflammation and ox-LDL-Induced Lipid Deposition
por: Xue, Feng, et al.
Publicado: (2017)

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H(2)S System
por: Peng, Juan, et al.
Publicado: (2017)

Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux
por: Zhang, Cheng, et al.
Publicado: (2023)

Ginsenoside Compound K Attenuates Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation via Autophagy Induction and Modulating NF-κB, p38, and JNK MAPK Signaling
por: Lu, Shan, et al.
Publicado: (2020)

Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage
por: Zhang, Heng, et al.
Publicado: (2015)

Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis
por: Poznyak, Anastasia V., et al.
Publicado: (2021)

Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling
por: Li, Ben, et al.
Publicado: (2022)

Curcumin Alleviates oxLDL Induced MMP-9 and EMMPRIN Expression through the Inhibition of NF-κB and MAPK Pathways in Macrophages
por: Cao, Jiatian, et al.
Publicado: (2017)

oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages
por: Wallner, Stefan, et al.
Publicado: (2016)

Reduced beta2-glycoprotein I protects macrophages from ox-LDL-induced foam cell formation and cell apoptosis
por: Wang, Wei-Lin, et al.
Publicado: (2013)

Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL
por: Kimmel, Danielle W., et al.
Publicado: (2017)

Ginsenoside Rg3 Alleviates ox-LDL Induced Endothelial Dysfunction and Prevents Atherosclerosis in ApoE(−/−) Mice by Regulating PPARγ/FAK Signaling Pathway
por: Geng, Jianan, et al.
Publicado: (2020)

Intermedin Inhibits the Ox-LDL–Induced Inflammation in RAW264.7 Cells by Affecting Fatty Acid–Binding Protein 4 Through the PKA Pathway
por: Liu, Kai, et al.
Publicado: (2021)

Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells
por: Cao, Hui, et al.
Publicado: (2019)

Apremilast ameliorates ox-LDL-induced endothelial dysfunction mediated by KLF6
por: Wang, Hao, et al.
Publicado: (2020)

SNHG1 Inhibits ox-LDL-Induced Inflammatory Response and Apoptosis of HUVECs via Up-Regulating GNAI2 and PCBP1
por: Lu, Yuan, et al.
Publicado: (2020)

Genome-wide profiling to analyze the effects of Ox-LDL induced THP-1 macrophage-derived foam cells on gene expression
por: Hu, Yan-Wei, et al.
Publicado: (2014)

Berberine Regulated miR150-5p to Inhibit P2X7 Receptor, EMMPRIN and MMP-9 Expression in oxLDL Induced Macrophages
por: Lu, Lin, et al.
Publicado: (2021)

Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology
por: Chen, Kuikui, et al.
Publicado: (2020)

Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential
por: Deng, Chang-Feng, et al.
Publicado: (2022)

Comparison of adipose- and bone marrow-derived stem cells in protecting against ox-LDL-induced inflammation in M1-macrophage-derived foam cells
por: Li, Jian-Zhong, et al.
Publicado: (2019)

LXRα Regulates oxLDL-Induced Trained Immunity in Macrophages
por: Findeisen, Hannes M., et al.
Publicado: (2022)

FGF21 protects against ox-LDL induced apoptosis through suppressing CHOP expression in THP1 macrophage derived foam cells
por: Li, En, et al.
Publicado: (2015)

Terminalia Arjuna bark extract impedes foam cell formation and promotes apoptosis in ox-LDL-stimulated macrophages by enhancing UPR-CHOP pathway
por: Bhansali, Shipra, et al.
Publicado: (2019)

Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction
por: Vrieling, Frank, et al.
Publicado: (2019)

Salvianolic Acid B and Ginsenoside Re Synergistically Protect Against Ox-LDL-Induced Endothelial Apoptosis Through the Antioxidative and Antiinflammatory Mechanisms
por: Yang, Ke, et al.
Publicado: (2018)

Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells
por: Qiao, Lei, et al.
Publicado: (2017)

GDF-15 Suppresses Atherosclerosis by Inhibiting oxLDL-Induced Lipid Accumulation and Inflammation in Macrophages
por: Huang, Hong, et al.
Publicado: (2021)

Azilsartan ameliorates ox-LDL-induced endothelial dysfunction via promoting the expression of KLF2
por: Li, Wenfeng, et al.
Publicado: (2021)

LOX-1, OxLDL, and Atherosclerosis
por: Pirillo, Angela, et al.
Publicado: (2013)

Corrigendum: Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells
por: Qiao, Lei, et al.
Publicado: (2018)

TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells
por: Li, B-H, et al.
Publicado: (2014)

OX(1) and OX(2) orexin/hypocretin receptor pharmacogenetics
por: Thompson, Miles D., et al.
Publicado: (2014)

SCD1 activation impedes foam cell formation by inducing lipophagy in oxLDL‐treated human vascular smooth muscle cells
por: Pi, Huifeng, et al.
Publicado: (2019)

Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis
por: Liu, Jiaru, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p20p1omj0rap5euc5u30qefcje