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Chromosome contacts in activated T cells identify autoimmune disease candidate genes

BACKGROUND: Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4(+) T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification of candidate disease genes. RESULTS: Within 4...

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Detalles Bibliográficos
Autores principales:	Burren, Oliver S., Rubio García, Arcadio, Javierre, Biola-Maria, Rainbow, Daniel B., Cairns, Jonathan, Cooper, Nicholas J., Lambourne, John J., Schofield, Ellen, Castro Dopico, Xaquin, Ferreira, Ricardo C., Coulson, Richard, Burden, Frances, Rowlston, Sophia P., Downes, Kate, Wingett, Steven W., Frontini, Mattia, Ouwehand, Willem H., Fraser, Peter, Spivakov, Mikhail, Todd, John A., Wicker, Linda S., Cutler, Antony J., Wallace, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584004/ https://www.ncbi.nlm.nih.gov/pubmed/28870212 http://dx.doi.org/10.1186/s13059-017-1285-0

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