Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination

BACKGROUND: Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid tumors. However, current inhibitors do not penetrate the blood-brain-barrier (BBB)...

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Detalles Bibliográficos
Autores principales: Zhang, Xin, Xu, Ran, Zhang, Chao, Xu, Yangyang, Han, Mingzhi, Huang, Bin, Chen, Anjing, Qiu, Chen, Thorsen, Frits, Prestegarden, Lars, Bjerkvig, Rolf, Wang, Jian, Li, Xingang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584019/
https://www.ncbi.nlm.nih.gov/pubmed/28870216
http://dx.doi.org/10.1186/s13046-017-0588-z

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