Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes

BACKGROUND: Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical setting. METHODS: We constructed type 5 Ad (Ad5) of which the expression of E1A...

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Detalles Bibliográficos
Autores principales: Yamauchi, Suguru, Zhong, Boya, Kawamura, Kiyoko, Yang, Shan, Kubo, Shuji, Shingyoji, Masato, Sekine, Ikuo, Tada, Yuji, Tatsumi, Koichiro, Shimada, Hideaki, Hiroshima, Kenzo, Tagawa, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584036/
https://www.ncbi.nlm.nih.gov/pubmed/28874135
http://dx.doi.org/10.1186/s12885-017-3621-x

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