The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway

BACKGROUND: The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (AC6-N, aa 1–86). Activation of AC6, rather than AC5, produ...

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Detalles Bibliográficos
Autores principales: Wu, Yu-Shuo, Chen, Chien-Chang, Chien, Chen-Li, Lai, Hsing-Lin, Jiang, Si-Tse, Chen, Yong-Cyuan, Lai, Lin-Ping, Hsiao, Wei-Fan, Chen, Wen-Pin, Chern, Yijuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584049/
https://www.ncbi.nlm.nih.gov/pubmed/28870220
http://dx.doi.org/10.1186/s12929-017-0367-3

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