Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP aggregates can promote the misfolding and aggregation of endogenous IAPP in isle...

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Detalles Bibliográficos
Autores principales: Mukherjee, Abhisek, Morales-Scheihing, Diego, Salvadores, Natalia, Moreno-Gonzalez, Ines, Gonzalez, Cesar, Taylor-Presse, Kathleen, Mendez, Nicolas, Shahnawaz, Mohammad, Gaber, A. Osama, Sabek, Omaima M., Fraga, Daniel W., Soto, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584114/
https://www.ncbi.nlm.nih.gov/pubmed/28765400
http://dx.doi.org/10.1084/jem.20161134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584114/
https://www.ncbi.nlm.nih.gov/pubmed/28765400
http://dx.doi.org/10.1084/jem.20161134

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