PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients

Patients with hypomorphic mutations in STAT3 and patients with hypermorphic mutations in STAT1 share several clinical and cellular phenotypes suggesting overlapping pathophysiologic mechanisms. We, therefore, examined cytokine signaling and CD4(+) T cell differentiation in these cohorts to character...

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Detalles Bibliográficos
Autores principales: Zhang, Yuan, Ma, Chi A., Lawrence, Monica G., Break, Timothy J., O’Connell, Michael P., Lyons, Jonathan J., López, Diego B., Barber, John S., Zhao, Yongge, Barber, Daniel L., Freeman, Alexandra F., Holland, Steven M., Lionakis, Michail S., Milner, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584116/
https://www.ncbi.nlm.nih.gov/pubmed/28710273
http://dx.doi.org/10.1084/jem.20161427

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