CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

Effective targeting of cancer stem cells (CSCs) requires neutralization of self-renewal and chemoresistance, but these phenotypes are often regulated by distinct molecular mechanisms. Here we report the ability to target both of these phenotypes via CD55, an intrinsic cell surface complement inhibit...

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Detalles Bibliográficos
Autores principales: Saygin, Caner, Wiechert, Andrew, Rao, Vinay S., Alluri, Ravi, Connor, Elizabeth, Thiagarajan, Praveena S., Hale, James S., Li, Yan, Chumakova, Anastasia, Jarrar, Awad, Parker, Yvonne, Lindner, Daniel J., Nagaraj, Anil Belur, Kim, J. Julie, DiFeo, Analisa, Abdul-Karim, Fadi W., Michener, Chad, Rose, Peter G., DeBernardo, Robert, Mahdi, Haider, McCrae, Keith R., Lin, Feng, Lathia, Justin D., Reizes, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584126/
https://www.ncbi.nlm.nih.gov/pubmed/28838952
http://dx.doi.org/10.1084/jem.20170438

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