Cargando…

Phospho-AXL is widely expressed in glioblastoma and associated with significant shorter overall survival

Receptor tyrosine kinase AXL (RTK-AXL) is regarded as a suitable target in glioblastoma (GBM) therapy. Since AXL kinase inhibitors are about to get approval for clinical use, patients with a potential benefit from therapy targeting AXL need to be identified. We therefore assessed the expression patt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Onken, Julia, Vajkoczy, Peter, Torka, Robert, Hempt, Claudia, Patsouris, Victor, Heppner, Frank L., Radke, Josefine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper: Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584143/ https://www.ncbi.nlm.nih.gov/pubmed/28881571 http://dx.doi.org/10.18632/oncotarget.18468

Ejemplares similares

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo
por: Onken, Julia, et al.
Publicado: (2016)

Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients
por: Radke, Josefine, et al.
Publicado: (2019)

Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma
por: Scherschinski, Lea, et al.
Publicado: (2022)

AXL is an oncotarget in human colorectal cancer
por: Martinelli, Erika, et al.
Publicado: (2015)

Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation
por: Lauter, Markus, et al.
Publicado: (2019)

Apelin Controls Angiogenesis-Dependent Glioblastoma Growth
por: Frisch, Anne, et al.
Publicado: (2020)

Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma
por: He, Xia, et al.
Publicado: (2019)

Reclassification of Glioblastoma Multiforme According to the 2021 World Health Organization Classification of Central Nervous System Tumors: A Single Institution Report and Practical Significance
por: Stoyanov, George S, et al.
Publicado: (2022)

Overall Survival Prediction of Advanced Cancer Patients by Selection of the Most Significant Baseline Serum Biomarker Combination
por: Deme, Daniel, et al.
Publicado: (2022)

Not All Monstrous Cells Indicate Glioblastoma: A Neuropathological Case Report of Pleomorphic Xanthoastrocytoma Misdiagnoses As Giant Cell Glioblastoma
por: Stoyanov, George S, et al.
Publicado: (2023)

Rapid Brainstem Infiltration of a Cerebellar Glioblastoma
por: De Jesus, Orlando, et al.
Publicado: (2022)

Corrigendum: Overall Survival Prediction of Advanced Cancer Patients by Selection of the Most Significant Baseline Serum Biomarker Combination
por: Deme, Daniel, et al.
Publicado: (2022)

Sodium ion channel mutations in glioblastoma patients correlate with shorter survival
por: Joshi, Avadhut D, et al.
Publicado: (2011)

Extracranial Glioblastoma Metastasis: A Neuropathological Case Report
por: Stoyanov, George S, et al.
Publicado: (2023)

Effectiveness of Immune Checkpoint Inhibition vs Chemotherapy in Combination With Radiation Therapy Among Patients With Non–Small Cell Lung Cancer and Brain Metastasis Undergoing Neurosurgical Resection
por: Wasilewski, David, et al.
Publicado: (2022)

Correlation of Tumor Pathology with Fluorescein Uptake and MRI Contrast-Enhancement in Stereotactic Biopsies
por: Xu, Ran, et al.
Publicado: (2022)

Primitive Neuroectodermal Tumor with Glioblastoma Multiforme Components in an Adult: A Collision Tumor
por: Forbes, Victoria, et al.
Publicado: (2016)

The Role of Preoperative Neutrophil, Platelet, and Monocyte to Lymphocyte Ratios as Independent Prognostic Factors for Patient Survival in WHO 2021 Glioblastoma: A Single-Center Retrospective Study
por: Stoyanov, George S, et al.
Publicado: (2022)

Does Elimination of a Laboratory Sample Clotting Stage Requirement Reduce Overall Turnaround Times for Emergency Department Stat Biochemical Testing?
por: Compeau, Sarah, et al.
Publicado: (2016)

ATM/RB1 mutations predict shorter overall survival in urothelial cancer
por: Yin, Ming, et al.
Publicado: (2018)

GDF11 upregulation independently predicts shorter overall-survival of uveal melanoma
por: Liu, Xun, et al.
Publicado: (2019)

Expression and significance of CHIP in canine mammary gland tumors
por: WANG, Huanan, et al.
Publicado: (2015)

The Significance of Topoisomerase II Alpha in Invasive Breast Carcinoma
por: Arthi, M, et al.
Publicado: (2021)

Clinical Correlation and Role of Cyclin D1 Expression in Glioblastoma Patients: A Study From North India
por: Jaiswal, Mamta, et al.
Publicado: (2022)

Emerging Bacterial Infection: Identification and Clinical Significance of Kocuria Species
por: Kandi, Venkataramana, et al.
Publicado: (2016)

Significance of Crushed Fragments and Eosinophils in Cytological Diagnosis of Hashimoto’s Thyroiditis
por: Khatri, Arti, et al.
Publicado: (2019)

Adequacy of Surgical Pathology Reports of Colorectal Carcinoma and Its Significance
por: Khan, Salahuddin, et al.
Publicado: (2021)

Clinicopathological and Immunohistochemistry Study of a Long Survivor of Giant Cell Glioblastoma in a Patient With Neurofibromatosis 1: Case Report
por: Al-romaihi, Noora, et al.
Publicado: (2023)

Significance of Nuclear Morphometry in Breast Lesions: A Cross-Sectional Study
por: Girdhar, Ankita, et al.
Publicado: (2023)

Hand and Foot Glomus Tumors: Significance of MRI Diagnosis Followed by Histopathological Assessment
por: Patel, Tarang, et al.
Publicado: (2022)

Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease
por: Kandi, Venkataramana, et al.
Publicado: (2016)

Increased Cancer Risk in Younger Patients with Thyroid Nodules Diagnosed as Atypia of Undetermined Significance
por: Todorovic, Emilija, et al.
Publicado: (2018)

Common Sensitive Diagnostic and Prognostic Markers in Hepatocellular Carcinoma and Their Clinical Significance: A Review
por: Samman, Basim Saleh, et al.
Publicado: (2022)

Serum Tumor Necrosis Factor-Alpha Levels in Acute Leukemia and Its Prognostic Significance
por: Verma, Sapana, et al.
Publicado: (2022)

The predominant expression of cancer stem cell marker ALDH1A3 in tumor infiltrative area is associated with shorter overall survival of human glioblastoma
por: Gan, Chao, et al.
Publicado: (2020)

Epidermal Growth Factor Receptor Variant III Mutation, an Emerging Molecular Marker in Glioblastoma Multiforme Patients: A Single Institution Study on the Indian Population
por: Garima, Garima, et al.
Publicado: (2022)

Prognostic Significance of the Dynamic Change of Programmed Death-ligand 1 Expression in Patients with Multiple Myeloma
por: Guan, Jian, et al.
Publicado: (2019)

Expression of p53 and p16 in Carcinoma Breast Tissue: Depicts Prognostic Significance or Coincidence
por: Rana, Manjit K, et al.
Publicado: (2021)

Prognostic Significance of Lymphovascular Invasion Detected by D2-40 in Low-Risk Stage II Colon Cancer
por: Prugmahachaikul, Anand, et al.
Publicado: (2021)

Locally dose-escalated radiotherapy may improve intracranial local control and overall survival among patients with glioblastoma
por: Zschaeck, Sebastian, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0njgiaf22dv9ufkacnui6hfhk0