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Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1

The HECT-type ubiquitin ligase Smurf1 (Smad ubiquitination regulatory factor-1) plays the prominent role in regulation of bone formation, embryonic development, and tumorigenesis by directing the ubiquitin-proteasomal degradation of specific targets. In contrast with RING-type E3s, the catalytic HEC...

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Detalles Bibliográficos
Autores principales:	Zhang, Yuan, Wang, Cheng, Cao, Yu, Gu, Yongqing, Zhang, Lingqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584161/ https://www.ncbi.nlm.nih.gov/pubmed/28881580 http://dx.doi.org/10.18632/oncotarget.10648

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