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A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus

Mutations in the Lamin A/C (LMNA) gene-encoding nuclear LMNA cause laminopathies, which include partial lipodystrophies associated with metabolic syndromes. The lipodystrophy-associated LMNA p.R482W mutation is known to impair adipogenic differentiation, but the mechanisms involved are unclear. We s...

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Detalles Bibliográficos
Autores principales:	Oldenburg, Anja, Briand, Nolwenn, Sørensen, Anita L., Cahyani, Inswasti, Shah, Akshay, Moskaug, Jan Øivind, Collas, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584164/ https://www.ncbi.nlm.nih.gov/pubmed/28751304 http://dx.doi.org/10.1083/jcb.201701043

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