Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells

Metformin inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which is frequently upregulated in hepatocellular carcinoma (HCC). Metformin has also been shown to induce apoptosis in this cancer. Here, we investigate whether metformin-induced apoptosis in HCC is mediated...

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Detalles Bibliográficos
Autores principales: Bhat, Mamatha, Yanagiya, Akiko, Graber, Tyson, Razumilava, Nataliya, Bronk, Steve, Zammit, Domenick, Zhao, Yunhao, Zakaria, Chadi, Metrakos, Peter, Pollak, Michael, Sonenberg, Nahum, Gores, Gregory, Jaramillo, Maritza, Morita, Masahiro, Alain, Tommy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584165/
https://www.ncbi.nlm.nih.gov/pubmed/28881582
http://dx.doi.org/10.18632/oncotarget.10671

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