Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification

Targeted therapy is not yet approved for esophageal cancer (EC). In this study, we first evaluated EGFR gene and protein expression in 70 Chinese EC patient tumor samples collected during surgery. We then established 23 patient-derived EC xenograft (PDECX) models and assessed the efficacy of theliat...

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Detalles Bibliográficos
Autores principales: Ren, Yongxin, Zheng, Jianming, Fan, Shiming, Wang, Linfang, Cheng, Min, Shi, Dongxia, Zhang, Wei, Tang, Renxiang, Yu, Ying, Jiao, Longxian, Ni, Jun, Yang, Haibin, Cai, Huaqing, Yin, Fang, Chen, Yunxin, Zhou, Feng, Zhang, Weihan, Qing, Weiguo, Su, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584209/
https://www.ncbi.nlm.nih.gov/pubmed/28881608
http://dx.doi.org/10.18632/oncotarget.17243

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