Engineering a high-affinity humanized anti-CD24 antibody to target hepatocellular carcinoma by a novel CDR grafting design

Cluster of differentiation 24 (CD24) is a specific surface marker involved in the tumorigenesis and progression of hepatocellular carcinoma (HCC). However, all reported anti-CD24 antibodies are murine ones with inevitable immunogenicity. To address this, a method using both molecular structure and d...

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Detalles Bibliográficos
Autores principales: Sun, Fumou, Wang, Tong, Jiang, Jiahao, Wang, Yang, Ma, Zhaoxiong, Li, Zhaoting, Han, Yue, Pan, Mingzhu, Cai, Jialing, Wang, Min, Zhang, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584245/
https://www.ncbi.nlm.nih.gov/pubmed/28881644
http://dx.doi.org/10.18632/oncotarget.17228

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