Identification of novel small molecule Beclin 1 mimetics activating autophagy

Anti-apoptotic proteins Bcl-2 and Bcl-xL could block autophagy by binding to Beclin 1 protein, an essential inducer of autophagy. Compounds mimicking Beclin 1 might be able to disrupt Bcl-xL/2-Beclin 1 interaction, free out Beclin 1, and thus trigger autophagy. In order to identify small molecule Be...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Jia, Lan, Lan, Lewin, Seth J., Rogers, Steven A., Roy, Anuradha, Wu, Xiaoqing, Gao, Philip, Karanicolas, John, Aubé, Jeffrey, Sun, Baiwang, Xu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584254/
https://www.ncbi.nlm.nih.gov/pubmed/28881653
http://dx.doi.org/10.18632/oncotarget.17977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584254/
https://www.ncbi.nlm.nih.gov/pubmed/28881653
http://dx.doi.org/10.18632/oncotarget.17977

Ejemplares similares