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Identification of novel small molecule Beclin 1 mimetics activating autophagy

Anti-apoptotic proteins Bcl-2 and Bcl-xL could block autophagy by binding to Beclin 1 protein, an essential inducer of autophagy. Compounds mimicking Beclin 1 might be able to disrupt Bcl-xL/2-Beclin 1 interaction, free out Beclin 1, and thus trigger autophagy. In order to identify small molecule Be...

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Detalles Bibliográficos
Autores principales:	Yu, Jia, Lan, Lan, Lewin, Seth J., Rogers, Steven A., Roy, Anuradha, Wu, Xiaoqing, Gao, Philip, Karanicolas, John, Aubé, Jeffrey, Sun, Baiwang, Xu, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584254/ https://www.ncbi.nlm.nih.gov/pubmed/28881653 http://dx.doi.org/10.18632/oncotarget.17977

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